脑胶质瘤组织中BMP-7与YY1 mRNA表达的相关性研究  

Expressions of BMP-2 and YY1 in human brain gliomas and their significance

作　　者：刘光辉[1] 李黎[2] 张帆[1] 

机构地区：[1]仙桃市第一人民医院神经外科,湖北仙桃433000 [2]武汉生物制品研究所,430060

出　　处：《中国临床神经外科杂志》2010年第2期98-100,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨骨形态形成蛋白-7(BMP-7)和Yin Yang-1(YY1)mRNA在不同级别脑胶质瘤组织中的表达及其生物学意义。方法采用定时荧光定量PCR技术检测56例胶质瘤组织及10例正常脑组织中BMP-7和YY1mRNA的表达水平,并分析其与胶质瘤病理学分级的关系。结果①BMP-7mRNA在胶质瘤标本中的表达量明显高于正常脑组织(P<0.01),并且其表达量随胶质瘤恶性程度的升高而增加(P<0.01);②YY1 mRNA在胶质瘤标本中的表达量明显高于正常脑组织(P<0.01),并且其表达量随胶质瘤恶性程度的升高而增加(P<0.01);③BMP-7和YY1mRNA表达量在胶质瘤中的表达呈正相关(r=15.831,P<0.01)。结论BMP-7和YY1 mRNA在胶质瘤组织中表达明显升高且两者表达均与胶质瘤的病理分级呈正相关。这提示BMP-7和YY1 mRNA的表达上调可能参与了胶质瘤的发生和发展,BMP-7和YY1可能能作为胶质瘤治疗的新靶点。Objective To investigate expressions of Bone morphogenetic protein-7 （BMP-7） and Yin Yang-1 （YY1） mRNA in human brain gliomas,and their relationship with the pathogenesis and development of the gliomas.Method The expressions of BMP-7 and YY1 mRNA in the gliomas tissues derived from 56 patients and normal cerebral tissues derived from 10 patients with traumanc brain injury were determined by quantitative reverse transcription polymerase chain reaction （QRT-PCR）.The relationship of BMP-7 and YY1 mRNA expressions with pathological grade of the gliiomas was analyzed.Results The expressions levels of BMP-7 and YY1 mRNA were significantly higher in gliomas tissues than those in the normal cerebral tissues （P〈0.01）.The expression levels of BMP-7 and YY1 in the gliomas tissues were positively related to the pathological grades of the gliomas （P〈0.01）.The BMP-7 mRNA expression was positively related to the expression of YY1 mRNA in the gliomas tissues（r=15.831,P〈0.01）.Conclusions It is suggested that the up-regulated expressions of BMP-7 and YY1 mRNA may play the important role in the pathogenesis and development of the gliomas.The inhibition of BMP-7 and YY1 expressions may be a potential method to treat the gliomas.

关 键 词：胶质瘤 骨形态形成蛋白 Ying Yang1 荧光定量PCR 

分 类 号：R739.41[医药卫生—肿瘤] R730.264[医药卫生—临床医学]