肿瘤的主动靶向给药系统研究现状  

Active tumor targeting drug delivery system:the current status

作　　者：丁宝月[1,2] 敖雷[2] 丁雪鹰[3] 高静[3] 范伟[1] 高申[1] 

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]嘉兴学院医学院药剂教研室,嘉兴314001 [3]第二军医大学药学院药剂学教研室,上海200433

出　　处：《第二军医大学学报》2010年第3期321-328,共8页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30973459);上海市科委纳米技术专项基金(0952nm02800)~~

摘　　要：主动靶向给药系统能使抗肿瘤药物选择性地与靶组织在细胞或亚细胞水平上结合并起作用,可使药物能够可控性地分布于靶区并持续缓慢地释放药物,在提高药物抗癌效果的同时可降低其对正常组织的不良反应。尽管开发研究主动靶向给药系统还有许多问题有待解决,广泛应用于临床尚需时日,但它们对于克服肿瘤治疗中的不良反应,提高疗效具有不可忽视的作用,是抗肿瘤药物的理想剂型,具有良好的应用前景。本文通过查阅大量近年来国内外主动靶向给药系统在肿瘤治疗中的相关研究文献,进行分析、归纳和总结,综述了在研并取得一定进展的抗肿瘤主动靶向给药系统的作用、特点、存在的问题及可能的解决方法,为肿瘤的靶向给药研究提供思路和方法。Active tumor targeting drug delivery system（ATTDDS） can selectively combine with and react to the target tissue at the cellular or sub-cellular level,making it possible for drugs to be distributed in a controlled manner and released in a slow and continuous manner,subsequently resulting in enhanced anti-cancer drugs effects and reduced adverse effects on normal tissues.Although there are many problems need to be solved in research on ATTDDS,and there is still a long way to go before it can be used clinically,its roles in overcoming adverse effects of cancer treatment and improving the therapeutic effect are valuable.Generally,ATTDDS is an ideal anti-tumor drug dosage and has a promising prospect.This paper introduces the effects and characteristics of various types of ATTDDS as well as their problems and countermeasures,hoping to provide research ideas and methods for the anti-tumor targeted drug delivery.

关 键 词：肿瘤治疗 主动靶向 给药系统 抗体 受体 肿瘤细胞 脂质体 偶联物 不良反应 特异性 

分 类 号：R730.53[医药卫生—肿瘤]