CD_(99)在淋巴造血系统的表达与功能  

Research Progress in Expression and Function of CD_(99) in Lymphatic and Hematopoietic System

作　　者：刘芳[1] 刘靖[1] 刘娜[1] 岳赟[2] 

机构地区：[1]佛山科学技术学院医学院生理病生教研室,广东佛山528000 [2]佛山科学技术学院医学院药理学教研室,广东佛山528000

出　　处：《医学综述》2010年第7期975-978,共4页Medical Recapitulate

基　　金：广东省自然科学基金博士启动项目(9452800001002250)

摘　　要：由MIC2基因所编码的人CD99是一种跨膜糖蛋白,在胸腺T淋巴细胞、前B细胞、中性粒细胞、单核细胞等淋巴造血细胞上有着特定的表达,它参与了胸腺细胞的阳性选择、T淋巴细胞的活化和凋亡、前B细胞的发育、中性粒细胞的渗出、单核细胞的游走等多种细胞事件。机制可能涉及非整合素介导的黏附过程,而其异常表达常常导致淋巴造血系统恶性肿瘤的发生。与人CD99高度同源的鼠源性CD99样抗原可能主要参与了炎性反应及免疫调节。Human CD99 is a trausmembrane glycoproteiu encoded by MIC2 gene, specifically expressed by thymic T lymphocytes, pre-B cells, neutrophils, monocytes and other lymphohematopoietic cells. CD99 is involved in such cellular events as the positive selection of thymocytes, the activation and apoptosis of T lymphocytes, the development of pre-B ceils, the exudation of neutrophils, and the migration of monocytes. The possible mechanism involves the non-integrin mediated adhesion while its abnormal expression usually results in the development of lymphatic and hematopoietic malignancies. Mouse-derived CD99-1ike antigen is highly homologous to human CD99 and likely to mainly participate in inflammatory reaction and immune regulation.

关 键 词：CD99 淋巴细胞 造血细胞 肿瘤 鼠CD99样抗原2 

分 类 号：R363[医药卫生—病理学]