伴有淋巴样间质的微结节型胸腺瘤临床病理特征  

Clinicopathological features of micronodular thymoma with lymphoid stroma

作　　者：冷冬妮[1,2] 王海[1] 吴波[1] 马恒辉[1] 周航波[1] 陆珍凤[1] 

机构地区：[1]南京军区南京总医院病理科,南京210002 [2]解放军第四五四医院病理科

出　　处：《医学研究生学报》2010年第3期246-248,共3页Journal of Medical Postgraduates

摘　　要：目的微结节型胸腺瘤是一种十分罕见的胸腺上皮性肿瘤,只占所有胸腺瘤的1%～5%,国内尚无报道。文中探讨伴有淋巴样间质的微结节型胸腺瘤(micronodular thymoma with lymphoid stroma,MNT)的临床病理特征。方法运用组织病理学和免疫组织化学方法研究1例女性,68岁MNT,复习临床资料,并复习文献。结果肿块位于前中纵隔,大小9 cm×7 cm×5 cm,切面实性,灰白灰黄色,质中。组织学以多发性由丰富的淋巴细胞间质分隔的散在上皮性结节为特征,淋巴样间质中含有明显的生发中心。免疫表型:上皮成分表达CKpan,间质淋巴细胞和结节内散在淋巴细胞表达CD20、TdT、CD3和CD5。结论MNT非常罕见,良性病程,预后好,其确诊依赖于病理组织学与免疫组化标记。Objective Micronodular thymoma with lymphoid stroma（MNT） is a rare kind of thymus epithelial tumor,which has not been reported in china by now.The incidence is about 1%-5%.This study is to investigate the clinicopathological characteristic of MNT.Methods A case of MNT was studied by histopathological and immunohistochemical techniques.The clinical data and the related literature were reviewed.Results The patient was female and 68 years old.The bump was found in the anteromedial mediastinum,9 cm×7 cm×5 cm in size.The tumor appeared on cross-sectional imaging as solid,gray in color with middling texture.Histologically,MNT was characterized by multiple nodules of epithelioid tumor cells separated by abundant lymphoid stroma with prominent germinal centers.The tumor appeared on cross-sectional imaging as solid,gray in color,the epithelial tumor cells were positive for CKpan and lymphocytes in the stroma and dispersed in the nodules were positive for CD20,TdT,CD3 and CD5.Conclusion MNT is a very rare tumor with benign course and fine prognosis.The diagnosis of MNT is based on its characterized histological and immunohistochemical features.

关 键 词：胸腺瘤 微结节 淋巴样间质 

分 类 号：R733[医药卫生—肿瘤]