高危型HPV感染与宫颈癌组织中IDO表达的相关性研究  

Correlation of high risk human papillomavirus infection and IDO expression in uterie cervical carcinoma

作　　者：陈琬玲[1,2] 杨承刚[1] 杨宏英[1] 卢玉波[1] 张红平[1] 严志玲[1] 黄云超[1] 

机构地区：[1]云南省昆明医学院第三附属医院,昆明650106 [2]武警云南省总队医院

出　　处：《山东医药》2010年第12期23-25,共3页Shandong Medical Journal

基　　金：云南省科技厅昆明医学院应用基础研究联合专项资金资助课题(2008CD033)

摘　　要：目的探讨吲哚胺2,3-二氧酶(IDO)在宫颈癌发生发展中的作用及其与高危型人乳头状瘤病毒(HR-HPV)感染之间的关系。方法我院经宫颈活检病理确诊为CINⅢ和宫颈浸润癌患者43例,同时期因子宫肌瘤行全子宫切除宫颈正常患者30例作为对照。采用第2代杂交捕获法(HC-2)HR-HPV DNA检测高危型HPV DNA,免疫组化染色方法检测IDO的表达。结果IDO和HR-HPV阳性率在宫颈原位癌和浸润癌组均显著高于正常宫颈组(P<0.01)。HR-HPV感染与IDO表达呈正相关(rs=0.759,P<0.01)。结论在HR-HPV感染的CINⅢ和宫颈浸润癌中,IDO出现过表达,可能与肿瘤免疫逃逸有关。IDO可能成为宫颈癌预后的预测因子及治疗靶点。Objective To investigate the role of indoleamine 2,3-dioxygenase （IDO） in uterie cervical carcinoma progression and its correlation with human papillomavirus （HR-HPV） infection. Methods Forty-three patients with CIN Ⅲ and invasive uterie cervical carcinoma and 30 normal cervical tissues were analyzed by immunohistochemistry for the expression of IDO. The high risk HR-HPV were detected by HC-2 HR-HPV DNA analysis. Results The positive rate of HR-HPV and IDO was significantly higher in CIN Ⅲ and invasive uterie cervical carcinoma than that in normal tissues. The overexpression of IDO was positively correlated with HR-HPV infection in cervical cancer （ rs = 0. 759, P 〈 0.01 ）. Conclusions The IDO overexpression in CIN Ⅲ and invasive uterie cervical carcinoma may associated with tumor immune escape mechanisms. IDO would be the prognostic factor and therapeutic target in the treatment of uterie cervical squamous carcinoma.

关 键 词：吲哚胺2 3-二氧酶 宫颈肿瘤 乳头状瘤病毒 免疫逃逸 

分 类 号：R737.33[医药卫生—肿瘤]