用PCNA和AgNoRs评价颊癌生长前沿细胞增殖活性及其与淋巴结转移的关系  

EVALUATING PROLIFERATING ACTIVITY AND METASTATIC POTENTIAL OF INVASIVE MARGINAL CELL IN CARCINOMA OF BUCCAL MUCOSA BY PCNA AND AGNORs TECHNIQUE

作　　者：龚莉[1] 何志秀[2] 卢勇[2] 周志瑜[2] 杨橙[2] 

机构地区：[1]泸州医学院病理学教研室,646000 [2]华西医科大学口腔医学院口腔病理教研室

出　　处：《泸州医学院学报》1998年第5期364-366,共3页Journal of Luzhou Medical College

基　　金：国家自然科学基金!39370741

摘　　要：目的：探讨颊癌生长前沿细胞的增殖活性及其与淋巴结转移的关系。方法：用抗PCNA和AgNoRs染色分析叙例有、无转移颊癌中生长前沿区细胞和中央区细胞的增殖活性。结果：生长前治区细胞的增殖活性高于中央区（P＜0．05），有转移组前治区细胞的增殖活性高于无转移组（P＜0．05）。结论：检测颊癌生长前治区细胞的增殖活性，有助于预测颇癌的浸润转移能力，判断患者的预后。To evaluate the proliferating activity and metastatic potential of cell of invasivemargins in carcinoma of buccal mucosa (CBM). Methods: 40 cases of CBM(20 with metastases, 20 with-out metastases)were evaluated using PCNA and AgNORs technique. Results: The proliferating index ofPCNA and AgNORs count of invasive marginal cell in CBM Were significantly higher than that of centralcell, The cases with metastases were significantly higher than the ones without metastases. Conclusion:The detection of proliferating activity of invasive marginal cell in CBM is useful for assessing invasive andmetastatic POtential and judging pognosis in CBM.

关 键 词：增殖细胞核抗原 颊癌 AGNOR染色 淋巴结转移 

分 类 号：R739.81[医药卫生—肿瘤]