Transcranial magnetic stimulation-induced finger force changes under various finger coordination patterns and target finger force phases  

作　　者：Xiaoying Wu Wensheng Hou Xiaolin Zheng Shan Shen Yingtao Jiang Jun Zheng Yan He 

机构地区：[1]Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China [2]Psychology Department, University of Surrey, Guildford, Surrey, Gu2 7XFI, UK [3]Department of Computer Science, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA [4]Department of Electrical and Computer Engineering, University of Nevada, Las Vegas, NV 89154, USA

出　　处：《Neural Regeneration Research》2010年第1期64-69,共6页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China, No. 30770546;30970758;Chongqing Natural Science Foundation, No. 2006BB2043; 2007BB5148

摘　　要：BACKGROUND： The detection of motor evoked potential is utilized to explore neuromuscular finger coordination. The influence of transcranial magnetic stimulation on finger force has been investigated mainly on a single finger, and only time-dependent increased target finger force has been detected in the finger force task. OBJECTIVE： To explore the neural mechanism of finger force coordination in the motor cortex by observing the influence of various finger coordination patterns and patterns of transcranial magnetic stimulation （TMS）-induced finger force changes. DESIGN, TIME AND SETTING： Neurophysiological and behavioral study was performed at the Biomedical Engineering Laboratory of Chongqing University from April to June 2008. PARTICIPANTS： A total of 10 healthy, university students, comprising 5 males and 5 females, aged 21-23 years, voluntarily participated in this study. All participants were right-handed, with normal or corrected vision. Individuals with upper limb complaints or other musculoskeletal disorders were excluded. METHODS： A target force-tracking task was conducted on the index finger, the index and middle fingers, and four fingers （index, middle, ring, and little）, respectively. Target force trace in a single trial consisted of a 6-second ramp phase, a 20-second constant phase, and a 6-second drop phase. During experimentation, an unpredictable single-pulse TMS （120% motor threshold） was applied to the primary motor cortex （M1） in each phase. MAIN OUTCOME MEASURES： Changes in peak force induced by TMS were obtained for each finger pattern during each force-tracking phase. Differences in force changes were tested between different finger pattems with regard to ramp, constant, and drop phases of target force. RESULTS： Under ramp, constant, and drop phases of target force, the increase in magnetic stimulation-induced finger forces changes positively correlated with the number of fingers involved in the force tracking task. The magnetic stimulation-induced force changesBACKGROUND： The detection of motor evoked potential is utilized to explore neuromuscular finger coordination. The influence of transcranial magnetic stimulation on finger force has been investigated mainly on a single finger, and only time-dependent increased target finger force has been detected in the finger force task. OBJECTIVE： To explore the neural mechanism of finger force coordination in the motor cortex by observing the influence of various finger coordination patterns and patterns of transcranial magnetic stimulation （TMS）-induced finger force changes. DESIGN, TIME AND SETTING： Neurophysiological and behavioral study was performed at the Biomedical Engineering Laboratory of Chongqing University from April to June 2008. PARTICIPANTS： A total of 10 healthy, university students, comprising 5 males and 5 females, aged 21-23 years, voluntarily participated in this study. All participants were right-handed, with normal or corrected vision. Individuals with upper limb complaints or other musculoskeletal disorders were excluded. METHODS： A target force-tracking task was conducted on the index finger, the index and middle fingers, and four fingers （index, middle, ring, and little）, respectively. Target force trace in a single trial consisted of a 6-second ramp phase, a 20-second constant phase, and a 6-second drop phase. During experimentation, an unpredictable single-pulse TMS （120% motor threshold） was applied to the primary motor cortex （M1） in each phase. MAIN OUTCOME MEASURES： Changes in peak force induced by TMS were obtained for each finger pattern during each force-tracking phase. Differences in force changes were tested between different finger pattems with regard to ramp, constant, and drop phases of target force. RESULTS： Under ramp, constant, and drop phases of target force, the increase in magnetic stimulation-induced finger forces changes positively correlated with the number of fingers involved in the force tracking task. The magnetic stimulation-induced force changes

关 键 词：transcranial magnetic stimulation finger force peak force changes finger combination 

分 类 号：R[医药卫生]