成人骨髓间充质干细胞对实体器官移植之影响 在诱导耐受中已成为有意义的候选细胞  

Influence of adult bone marrow mesenchymal stem cells on solid organ transplantation:Significant candidate cells during tolerance induction

作　　者：刘奎利[1] 石炳毅[1] 

机构地区：[1]解放军总医院第二附属医院器官移植中心,北京市100091

出　　处：《中国组织工程研究与临床康复》2010年第1期147-151,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:来源于成人骨髓的间充质干细胞在体内外能够改变同种异体免疫反应,在实体器官移植中具有很大的应用潜力。目的:发展间充质干细胞的抗排斥治疗,进一步明确间充质干细胞免疫调节能力的机制。方法:应用计算机检索Pubmed数据库(1994/2009-03),以Mesenchymal stem cells,Solid organ transplantation,Tolerance,Immunosuppression,Animal model为检索词。结果与结论:共收集262篇关于成人骨髓间充质干细胞对实体器官移植的影响及作用机制的文献,全部为英文。排除发表时间较早、重复及类似研究,纳入49篇符合标准的文献。人间充质干细胞不表达MHC2Ⅱ类抗原和T细胞共刺激分子B7,与同种异体T淋巴细胞共培养不引起T细胞增殖,此外还抑制混合淋巴细胞反应及丝裂原刺激的T细胞增殖。间充质干细胞对T细胞增殖的抑制作用不受主要组织相容性复合物的限制,无论是来自供者、受者的间充质干细胞均具有相似的免疫调节作用。异基因间充质干细胞在体内能够引起免疫反应,不是完全免疫豁免的。间充质干细胞在注射后,在体内的效应强烈依靠其位置和迁移模式。在诱导耐受的临床器官移植研究中,间充质干细胞是有意义的候选细胞。BACKGROUND： Mesenchymal stem cells （MSCs） from adult bone marrow can alter alloimmune response in vitro and vivo. Thei potentiality is great in solid organ transplantation. OBJECTIVE： To develop MSC antirejection therapy and identify behind mechanishm of MSCs immunomodulation ability. METHODS： We searched Pubmed （1994-Mar.2009） with the key words of ＂mesenchymal stem cells, solid organ transplantation tolerance, immunosuppression, animal model＂ . RESULTS AND CONCLUSION： Totally 262 English articles about influence and mechanism of action of adult bone marrow mesenchymal stem cells on solid organ transplantation were collected. The 49 suitable articles were included without earlier publication time, repeated and analogous study. Human mesenchymal stem cells did not express MHC2 Ⅱ antigen and T cell costimulatory molecules B7. Coculture with allogenic T lymphocytes could not induce T cell proliferation, but inhibited mixed lymphocyte reaction and mitogenstimulated T cell proliferation. Inhibitory effects of mesenchymal stem cells on T cell proliferation were not limited by major histocompatibility complex. Mesenchymal stem cells no matter from donors or recipients had similar immunoloregulation effects. Allogene mesenchymal stem cells could cause immunereaction in vivo, no complete immune privilege. The in vivo effects of mesenchymal stem cells will strongly depend on their localization and migration pattern after injection. Therefore, MSCs are interesting candidate cells for tolerance induction in clinical organ transplantation.

关 键 词：移植 免疫调节 人 骨髓间充质干细胞 干细胞 

分 类 号：R394.2[医药卫生—医学遗传学]