情绪记忆中杏仁核和海马作用的fMRI  

Role of Amygdala and Hippocampus in Emotional Memory:Study with Functional MRI

作　　者：吴凡[1] 王海宝[1] 余永强[1] 

机构地区：[1]安徽医科大学第一附属医院放射科,合肥230022

出　　处：《放射学实践》2010年第3期276-279,共4页Radiologic Practice

基　　金：国家自然科学基金资助课题(30870712);安徽省自然科学基金资助课题(50430601)

摘　　要：目的:通过行为学和功能磁共振成像方法,检测杏仁核和海马激活情况,探讨内侧颞叶结构参与情绪记忆增强效应的认知神经机制。方法:20例受试者,实验材料采用160帧彩色情景图片。实验过程分为编码和提取两个阶段,编码阶段要求受试者观看图片并记住,编码同时进行功能磁共振扫描,提取阶段将80帧旧图片和80帧新加入的图片随机呈现,要求受试者通过按键尽快且尽可能准确地判断新、旧图片,记录行为学成绩。采用SPM2分析软件对功能成像数据进行分析。结果:受试者对情绪图片的记忆成绩为(2.82±0.16)分,较中性图片的记忆成绩(1.75±0.18)分显著增强(t=3.73,P<0.001);功能成像显示,双侧杏仁核(左侧:r=0.49,P=0.028,右侧:r=0.66,P=0.001)和海马(左侧海马和海马旁回r=0.56,P=0.010,右侧海马r=0.70,P=0.001)与增强效应显著相关(类聚块阈值r>0.44,P<0.05)。结论:情绪增强效应主要与杏仁核和海马密切相关,提示内侧颞叶在情绪记忆中具有重要作用。Objective： To study the cognitive mechanism of involvement of medial temporal lobe in the enhancement effects of emotional memory,with the examination of activation of amygdala and hippocampus by behavioral and functional magnetic resonance imaging （fMRI）. Methods：20 subjects were recruited and 160 colorful scene pictures were adopted. Experimental procedures included two sessions：encoding and retrieval. During encoding, the subjects were required to watch pictures and remember them as far as possible,while fMRI scans were performed. In retrieval session,80 ＂old＂ pictures and 80 ＂new＂ pictures were presented randomly, the subjects were required to judge the pictures （old/new） by pressing the mouse （pressing the left button as old picture and the right one as new） as fast and accurate as possible, their behavioral performances were recorded. SPM2 software was used to analyze the fMRI data. Results：The results of remembering emotional pictures （d＇=2.82 ± 0. 16） were much better than the neutral ones （d＇= 1. 75 ±0. 18）, with significant statistical difference （t=3.73,P〈0. 001）. On fMRI,the activations of bilateral amygdala （left：r=0.49,P=0. 028, right：r=0.66, P = 0.001 ） and hippocampus （ left ： r= 0.56, P = 0.010, right ： r = 0.70, P = 0.001 ） were significantly well correlated with emotional enhancement effects （threshold value of cluster was more than 0.44, P〈0. 05）. Conclusion： Emotional enhancement of memory was closely associated with amygdala and hippocampus,suggesting that the medial temporal lobe is an important structure involved in emotional memory.

关 键 词：情绪记忆 杏仁核 海马 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]