CgA在人乳腺组织中的表达及意义  

Expression of chromogranin A in human mammary tissues

作　　者：陈颖欣[1] 李连宏[1] 孙杰[1] 王波[1] 王丽霞[1] 

机构地区：[1]大连医科大学中日临床病理中心,辽宁大连116027

出　　处：《南方医科大学学报》2010年第3期547-548,551,共3页Journal of Southern Medical University

基　　金：辽宁省科学技术基金(20042136)

摘　　要：目的通过检测嗜铬蛋白A(CgA)在人乳腺组织中的表达探讨乳腺神经内分泌癌发病机制。方法免疫组化方法检测CgA在89例人乳腺组织中的表达情况。结果CgA在乳腺正常和增生组织中均没有表达,在乳腺癌组织中有表达,发生率16.7%,其表达在癌组织与非癌组织中存在显著差异,在不同病理分级乳腺癌的表达无差异。结论乳腺神经内分泌癌发生原因可能是干细胞受微环境因素影响在细胞分化不成熟的同时出现其他方向分化或转分化;可考虑将CgA作为常规检测项目筛查此类型乳腺癌的。Objective To explore the pathogenesis and significance of neuroendocrine breast carcinoma by detecting chromogranin A （CgA） in human mammary tissues. Method Eighty-nine cases of human mammary tissues were collected to detect CgA expression using immunohistochemistry. Result No CgA expression was detected in normal or hyperplastic tissues, but its expression was found in mammary carcinoma tissues at the rate of 16.7%. A significant difference in CgA expression was found between cancer tissues and non-cancer tissues, but not between the cancer tissues with different pathological grades. Conclusion The pathogenesis of mammary neuroendocrine carcinoma may involve the micro-environmental factors that affect the differentiation of stem cells to give rise to immature cells, cell differentiation in other lineages or transdifferentiation. CgA may serve as an immunological parameter for this type of breast cancer in routine screening test.

关 键 词：乳腺神经内分泌癌 乳腺 乳腺增生 嗜铬蛋白A 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]