乳腺癌PRL-R与ER、PR表达状况的关联性  

The correlation between the expression of PRL-R and ER/PR in breast cancer

作　　者：郑荣辉[1] 管迅行[2] 张秀萍[1] 何振宇[2] 黄赖机[1] 廖志伟[2] 童琴[2] 

机构地区：[1]广州医学院附属肿瘤医院放疗科,广东广州510095 [2]中山大学肿瘤防治中心放疗科,广东广州510060

出　　处：《南方医科大学学报》2010年第3期596-598,共3页Journal of Southern Medical University

摘　　要：目的PLR-R结合PRL后所引发生物学效应能促进乳腺癌的发生和进展。本研究旨在探讨乳腺癌PRL-R表达与ER、PR的关联性,并分析CerbB-2表达对此关联性的影响。方法收集2000年1月～2001年6月中山大学肿瘤防治中心收治的130例乳腺癌患者(中位年龄46岁)。采用免疫组化法检测各患者原发灶标本中PRL-R的表达。采用χ2关联性检验分析乳腺癌PRL-R表达与ER、PR的关联性。结果130例患者中PRL-R阳性表达89例(68.5%)。分析发现,全组病例PRL-R表达阳性率与ER表达呈正关联(P<0.05),但此关联性仅限于CerbB-2阳性表达亚层中出现(P<0.05)。全组病例PRL-R表达阳性率与PR表达无关联(P>0.05),但在CerbB-2阳性表达病例中,两者却表现为正关联(P<0.05)。结论乳腺癌PRL-R与ER/PR表达间的正关联性有赖于CerbB-2的阳性表达,CerbB-2表达状况对PRL-R与ER/PR表达间的关联性存在较大影响。Objective To investigate the correlation of prolactin receptor （PRL-R） expression to estrogen receptor （ER） and progesterone receptor （PR） expressions in primary breast cancer. Methods For 130 female patients with breast cancer （median age 46 years）, PRL-R expression in the primary tumor was detected by immunohistochemistry, and the correlation between PRL-R and ER/PR expressions was analyzed statistically. Results PRL-R positivity in the primary tumor was found in 89 of the patients （68.5%）, and the positivity rate for PRL-R was positively correlated to ER expression （P0.05）. Further stratification ofthe patientsaccordingto the CerbB-2 statusrevealed such a correlation onlyin CerbB-2-positive patients （P0.05）. In the patient cohort, no significant correlation was foundin the positivity rate between PRL-R and PR expressions （P0.05）, but in CerbB-2-positive patients, the positivity rate of PRL-R showed a positive correlation to PR expression （P0.05）. Conclusion The positive correlations in positivity rate between the PRL-R and ER/PR expressions are found only in CerbB-2 positive patients with breast cancer, and the expressional status of CerbB-2 affects the correlation between PRL-R and ER/PR expression in breast cancer.

关 键 词：乳腺癌 泌乳素受体 雌激素受体 孕激素受体 免疫组织化学法 

分 类 号：R737.9[医药卫生—肿瘤]