颅内血管外皮细胞瘤瘤周水肿与肿瘤侵袭性的关系  

Relationship between peritumoral edema on MRI and tumor cell invasion in intracranial haemangiopericytoma

作　　者：董驰[1] 周俊林[2] 段国兰[1] 朱薇[1] 张虹[1] 

机构地区：[1]兰州大学第二医院病理科,730030 [2]兰州大学第二医院放射科,730030

出　　处：《临床神经外科杂志》2010年第1期17-20,共4页Journal of Clinical Neurosurgery

基　　金：兰州市科技计划项目(项目编号:07-1-84)

摘　　要：目的探讨颅内血管外皮细胞瘤(HPC)MRI显示的瘤周水肿与Ki67因子表达的相关关系。方法采用免疫组织化学法(S-P法),用抗Ki67抗体对29例颅内血管外皮细胞瘤组织标本和25例血管瘤型脑膜瘤标本进行标记并分析,对MRI图像上显示的瘤周水肿情况进行评分,对照做相关分析。结果 29例颅内血管外皮细胞瘤Ki67均呈阳性表达,与对照组血管瘤型脑膜瘤组之间具有统计学意义(P<0.01);随着肿瘤瘤周水肿MRI评分的增高,Ki67阳性表达水平也升高(P<0.05)。结论颅内血管外皮细胞瘤MRI表现瘤周水肿与肿瘤Ki67蛋白的表达程度相关,可做为临床分析肿瘤治疗和预后的参考。Objective To investigate the correlation between peritumouous edema on MRI signs and Ki67 protein expression in intracranial haemangiopericytoma. Methods Ki67 protein expressions were detected by S-P immunohistochemical method in 29 cases with intracranial haemangioperi-cytoma and 25 cases of angiomatous type meningioma. Results 29 cases showed for the positive expression, and there was significant difference in the expression of Ki67 between intracranial haemangiopericytoma and angiomatous meningioma （P 〈0.01 ）. The positive expression of Ki67 protein was increasing while increasing of peritumouous edema signs on MRI in intracranial haemangiopericytoma （ P 〈 0.05 ）. Conclusions Peritumoral edema signs on MRI are closely related to the high expressions of Ki67 protein in intracranial haemangiopericytoma. It can be used as a reference in evaluating the treatment and prognosis of intracerebral haemangiopericytoma.

关 键 词：颅内血管外皮细胞瘤 磁共振 KI67蛋白 

分 类 号：R739.41[医药卫生—肿瘤]