TK1在乳腺癌中的表达及与Ki67表达的关系  

Expression of TK1 in the breast carcinoma and its relationship with Ki67

作　　者：陈秀娇[1] 陈建阳[2] 陈智伟[2] 蔡庆发[2] 张鹏飞[3] 

机构地区：[1]莆田学院医学院基础部,351100 [2]莆田学院附属医院病理科 [3]福建医科大学病理学系

出　　处：《中国医师进修杂志》2010年第8期5-7,共3页Chinese Journal of Postgraduates of Medicine

基　　金：基金项目：福建省教育厅基金（JA06041）

摘　　要：目的探讨TK1在乳腺癌发生、发展中的意义及与Ki67表达的相关性。方法应用免疫组织化学SABC法和S-P法检测TK1和Ki67在89例乳腺癌组织中的表达。结果TK1在乳腺癌组织中阳性表达率为69．7％（62／89），且与淋巴结转移、TNM分期、组织学分级密切相关（P〈0．05），与患者年龄无关（P〉0．05）。乳腺癌组织中TK1表达与Ki67表达没有显著的相关性（P〉0．05）。结论TK1表达与乳腺癌的发生、发展密切相关，其高表达是乳腺癌预后不良的指标。TK1和Ki67是独立的乳腺癌细胞增殖指标。Objective To explore the expression of TK1 in breast carcinoma and discuss its significance of carcinogenesis and progression in breast carcinoma and its relationship with Ki67. Method Using immunohistochemistry methods of SABC and S-P to detect the expression of TK1 and Ki67 in 89 cases of breast carcinoma tissue. Results Positive rate of TK 1 in the breast carcinoma was 69.7% （62/89）, and the expression of TK1 was significantly associated with lymph node metastasis, TNM stage and histological grade （P 〈0.05）, but it was not significantly correlated with age （P 〉0.05）. The expression of TK1 was not significantly correlated with Ki67 in the breast carcinoma （P 〉 0.05 ）. Conclusions Expression of TK1 is associated with carcinogenesis and progression, and it is a poor prognostic marker of breast carcinoma. TK 1 and Ki67 are the indicators of cellular growth independently.

关 键 词：乳腺肿瘤 免疫组织化学 TK1 KI67 

分 类 号：R737.9[医药卫生—肿瘤]