溃疡性结肠炎缓解期服用益生菌制剂维持治疗的Meta分析  

The effect of probiotics in maintaining remission of ulcerative colitis:a meta analysis

作　　者：牛小平[1] 韩真[1] 刘少锋[1] 

机构地区：[1]皖南医学院附属弋矶山医院消化内科,安徽芜湖241001

出　　处：《中国微生态学杂志》2010年第3期261-263,共3页Chinese Journal of Microecology

摘　　要：目的系统评价益生菌制剂用于溃疡性结肠炎（ulcerative colitis,UC）缓解期维持治疗的疗效。方法采用计算机检索和手工检索两种方法,以益生菌及其近义词、溃疡性结肠炎等主题词检索Cochrane国际协作网随机对照试验（RCT）注册数据库、PubMed、Embase数据库和中国期刊网等数据库（1978-2009）,所选文献符合缓解期UC的诊断标准,以美沙拉嗪为对照的随机对照试验。采用Cochrane系统评价员手册4.2.2推荐的方法纳入文献,并对其进行Meta分析。结果共纳入6个RCT,包括629名患者,Meta分析结果显示：临床复发率益生菌组与美沙拉嗪差异无显著性（OR=0.84,95%CI：0.59-1.19,P=0.33）。结论益生菌制剂与美沙拉嗪对于UC缓解期维持治疗的疗效相近,益生菌制剂是有效的溃疡性结肠炎缓解期维持治疗药物。Objective To evaluate the effect of probiotics on the maintenance of remission in ulcerative colitis （UC）. Method Computerized and manual search methods were used to retrieve literature. Published studies on the treatment of UC involving probiotics from 1978-2009 were identified by searching the library Cochrance, PubMed, Embase and Chinese Biomedical Literature Database using the key words ＂probiotic, ulcerative colitis＂. We selected only those randomly controlled clinical studies compared with mesalazine. Literature were included in accordance with Cochrane system atic review guideline 4.2.2. Meta analysis was performed to evaluate the data. Result Six trials inVolving 629 patients were included. The results of meta analysis demanstrated that probiotics alone on the maintenance of remission had the same relapse rate as mesalazine （OR =0.84;95%CI：0.59 to 1.19,P =0.33）during 12 to 48 weeks＇ follow up. Conclusion Pro- biotics demonstrated the same therapeutic efficacy as mesalazine onthe maintenance of remission in UC. Probiotics are potent drug on the maintenance of remission in UC.

关 键 词：益生菌制剂 美沙拉嗪 溃疡性结肠炎 维持治疗 META分析 

分 类 号：R574.62[医药卫生—消化系统]