MRI定量指标用于评定甲状腺相关眼病活动分期的可行性探讨——附84例报告  

Application of MRI quantitative analysis to assess the activity and staging of thyroid-associated ophthalmopathy:a report of 84 cases

作　　者：范艳飞[1,2] 沈洁[1] 李际敏[1] 刘仕群[1] 戈荧[1] 李云倩[1] 陈志[1] 

机构地区：[1]南方医科大学附属南方医院内分泌代谢科,510515 [2]广州军区广州总医院内分泌科,510010

出　　处：《新医学》2010年第3期160-163,共4页Journal of New Medicine

摘　　要：目的:探讨MRI定量指标用于评定甲状腺相关眼病(TAO)活动分期的可行性。方法:84例双眼受累的TAO患者(TAO组)根据临床活动评分分为活动期组(68例)、稳定期组(16例),另选择25名正常人为健康对照组。所有受试者行MRI眼眶扫描,检测眼球突出值、眼外肌短径及长径,计算眼外肌短长径比值。对TAO活动期组及稳定期组患者加测眼外肌T2弛豫时间、眼外肌及同侧颞肌相对T2信号,计算T2信号强度比值。结果:TAO组眼球突出值及各眼外肌短长径比值均明显大于健康对照组(P均<0.01)。TAO活动期组的T2弛豫时间、眼外肌信号强度比值与稳定期组比较差异均有统计学意义(P均<0.01),两组的眼球突出值、眼外肌短长径比值比较差异均无统计学意义(P均>0.05)。结论:MRI定量指标中的T2弛豫时间、T2信号强度比值可显示TAO患者的临床活动情况,可考虑作为TAO活动分期的量化指标。Objective： To explore the feasibility of MRI in the assessment of activity and staging of thyroid-associated ophthalmopathy （TAO）. Methods： Eighty-four patients with TAO of double sides （TAO group） were included and assigned into active stage group （n =68） and stable stage group （n=16）. Meanwhile, 25 normal people were selected as control group. MRI orbital scan was performed in each subject to assess the values of exophthalmos, short and long diameters of extraocular muscles. Ratios of short diameter to long diameter of extraocular muscles were calculated. Time of T2 relaxation, T2 signal intensity of extraocular muscles and homonymy temporal muscle were measured to calculate the ratios of T2 signal intensity. Results： Exophthalmos value and ratios of short diameter to long diameter of extraocular muscles of TAO group was significantly higher than those of control group （P 〈0. 01 ）, while there was no differences between the active and stable stage group in these parameters. There were significant differences between active stage group and stable stage group in the time of T2 relaxation and ratios of T2 signal intensity of extraocular muscles （ P 〈 0. 01 ）. Conclusion ： The time of T2 relaxation and ratios of T2 signal intensity of extraocular muscles in MRI are useful parameters to show the clinical activity of TAO and can be considered as the quantitative parameters to assess the activity and staging of TAO.

关 键 词：甲状腺相关眼病 磁共振成像 定量指标 活动分期 临床活动评分 

分 类 号：R771.3[医药卫生—眼科]