卡巴胆碱对急性胰腺炎大鼠胆碱能抗炎通路影响研究  

The research on how the carbachol affect in laboratory rats with acute pancreatitis

作　　者：宋斌[1] 党星波[1] 杨培新[1] 韩希望[1] 

机构地区：[1]陕西省人民医院急诊外科,西安710068

出　　处：《陕西医学杂志》2010年第3期309-311,共3页Shaanxi Medical Journal

基　　金：陕西省科技厅社会发展公关项目(2007K09-04)

摘　　要：目的:探讨卡巴胆碱对急性胰腺炎大鼠胆碱能抗炎通路的影响。方法:大鼠90只,随机分为假手术组,对照组,卡巴胆碱组各30只,分别测定3组动物模型建立成功后6h血清中IL-6、IL-1、TNF-α的含量变化。结果:卡巴胆碱组血清IL-6、IL-1及TNF-α水平高于假手术组,但低于对照组,假手术组各细胞因子均处于较低水平,结论:卡巴胆碱肠道给药通过胆碱能抗炎通路,能够降低胰腺炎大鼠血清损伤性细胞因子TNF-α、IL-6、IL-1的释放。Objective：To investigate how the Carbachol affect in laboratory rats with acute pancreatitis the cholinergic anti-inflammatory pathway influncing the cytokine level in laboratory rats with pancreatitis.Methods：90 Wistar rats were randomly divided into sham group（SG）,control group（CG）and Carbachol group（CAG）,serum cytokines content variation of TNF-α,IL-6,IL-10 in different period were determined.Results：Serum concentrate of cytokines in SG keep a low level,but what in CG were higher than that in SG,which is signifficant statistically.The concentrate of TNF-α,IL-6,IL-1 in CAG were higher than that in SG,But much lower than that in CG.Conclusion：Carbachol to dosage jejunum could decreased injury cytokines TNF-α,IL-6 IL-1 content.

关 键 词：胰腺炎/免疫学 @胆碱能抗炎通路 拟胆碱脂酶 细胞因子类/分析 模型 动物 大鼠 

分 类 号：R576[医药卫生—消化系统]