支气管肺癌在不同性别及年龄间差异的临床研究  

Differences of lung cancer in different gender and ages

作　　者：隋大鸣[1] 蒋鑫[1] 房蒙[1] 潘科[1] 徐松翠[1] 庞帅[2] 王桂芳[3] 

机构地区：[1]第二军医大学第二临床医学院,上海市200003 [2]第二军医大学附属长征医院呼吸内科,上海市200003 [3]复旦大学附属中山医院呼吸内科,上海市200032

出　　处：《实用医学杂志》2010年第5期753-757,共5页The Journal of Practical Medicine

摘　　要：目的:研究支气管肺癌(简称肺癌)在男性和女性患者间的差异及年龄对肺癌的影响。方法:将1003例肺癌患者分别按性别和年龄分组,其中<40岁定义为青年组,≥80岁定义为老年组,对患者资料进行回顾性分析。结果:男性患者鳞癌和小细胞肺癌的患病率高于女性(35.7%vs7.4%,P=0.001;9.6%vs3.5%,P<0.001),腺癌患病率则低于女性(49.9%vs84.9%,P<0.001),其Ⅲ期肺癌患者比例较女性高(37.6%vs27.6%,P=0.005),Ⅳ期肺癌患者比例较低(29.4%vs38.3%,P=0.010)。男性患者中咯血症状较明显(32.3%vs20.0%,P<0.001)。男女肺癌患者比例随着年龄的增加而增加。青年组和老年组非小细胞肺癌晚期患者所占比例较其他年龄组高(P<0.001),气急、体重减轻、胸腔积液和无临床症状的患者在各年龄组中的比例差异均有显著性(均P<0.05)。结论:不同性别肺癌有各自的临床和组织学特征,造成该差异的原因可能与烟草、激素等因素有关。不同年龄肺癌患者有其各自显著特征。Objective To investigate the differences of tung cancer between males and females and the effect of age on this malignancy. Methods 1 003 patients were grouped according to gender and age. Retrospective analysis was carried out to compare the clinico-pathologie features in different gender and age groups. Results The incidence of squamous cell carcinoma or small cell lung cancer was higher in male than in female （35.7% vs. 7.4%, P = 0.001; 9.6% vs. 3.5%, P 〈 0.001 ）, but that of adenoearcinoma was lower in male group （49.9% vs. 84.9%, P 〈 0.001 ）. More male patients had Ⅲ stage disease than female patients, but fewer male patients had IV stage disease in NSCLC （37.6% vs. 27.6%, P = 0.005; 29.4% vs. 38.3%, P = 0.010）. More males occurred hemoptysis than females （P 〈 0.001 ）. Male/female ratio increased with age. There were more patients with advanced stage NSCLC in the group with age 〈 40 or ≥ 80 （P 〈 0.001 ）. The percentage of patients with breath lessness, weight loss, or pleural effusion, or that of asymptomatic patients differed remarkably among various age groups （P 〈 0.05 for all comparisons）. Conchlsions Lung cancer in male has different clinico-pathologic features from that in female, which may be associated with tobacco and hormone. Patients at different ages have their own clinical characteristics.

关 键 词：肺肿瘤 性别 年龄 

分 类 号：R734.2[医药卫生—肿瘤]