胃癌细胞核形态分析的多参数定量研究  

A multi-parameter quantitative study on the morphometric analysis of the nuclei of gastric cancer cells

作　　者：龚平[1] 郭华雄[1] 汤绍迁[2] 张克难[3] 王向阳[3] 王静[2] 

机构地区：[1]华中科技大学同济医学院附属荆州医院病理科,湖北省荆州市434020 [2]华中科技大学同济医学院附属荆州医院消化内科,湖北省荆州市434020 [3]华中科技大学同济医学院附属荆州医院胃肠外科,湖北省荆州市434020

出　　处：《实用医学杂志》2010年第5期853-854,共2页The Journal of Practical Medicine

基　　金：湖北省卫生厅科研基金资助项目(编号:JX3B90);湖北省教育厅重大科研项目资助(编号:.Z200612001)

摘　　要：目的:探讨多参数的形态定量分析对胃癌及胃良性病变的鉴别价值。方法:利用HMIAS-2000医学图文分析测量系统,对20例慢性胃炎及45例胃癌的组织病理学切片中的腺上皮细胞细胞核进行多参数的形态测定。结果:在22个形态定量参数中,12项胃良性病变与胃癌有显著统计学差异(P<0.01),3项有统计学差异(P<0.05),7项无统计学差异(P>0.05)。结论:多参数的形态计量揭示了胃癌与胃良性病变的细胞核形态学计量特征,对辅助鉴别诊断具有一定的意义。Objective To explore the differential value of multi-parameter quantitative analvsis on the nuclear morphology in gastritis and gastric cancer. Methods Using multimedia image analytical system （HMIAS-2000）, We conducted muhi-parameter morphometry for the nuclei of the glandular epithelial cells from the pathology sections of 20 cases of gastritis and 45 cases of gastric cancer. Results Of 22 parameters, 12 differed significantly between gastritis and gastric cancer （P 〈 0.01 ）, 3 differed moderately （P 〈 0.05）, and 7 did not differed （P 〉 0.05）. Conclusions Multiparameter morphometry shows the morphological features of the nuclei of gastric cancer cells and non-cancer cells. It plays a role in the differential diagnosis of gastritis and gastric cancer.

关 键 词：胃肿瘤 慢性胃炎 细胞核 多参数 定量研究 

分 类 号：R735.2[医药卫生—肿瘤]