机构地区:[1]首都医科大学宣武医院放射科,北京100053 [2]GE中国CT影像研究中心
出 处:《中华放射学杂志》2010年第3期249-254,共6页Chinese Journal of Radiology
摘 要:目的探讨利用容积穿梭扫描模式(volume shuttle)的80mm CTP)及80mm动态4D—CTA诊断大脑Willis环血管狭窄或闭塞。方法55例大脑中动脉(MCA)或颈内动脉(ICA)重度狭窄或闭塞患者,行CT平扫、脑CTP和头颈部CTA检查,CTP检查获得脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTF)、达峰时间(TTP)等参数,同时获得80mm(0.625mm×128)扫描覆盖范围内动态4D-CTA。采用K Independent Samples分析ICA或MCA狭窄或闭塞者脑血流灌注参数CBF、CBV、MTT、TTP。结果40例单侧MCA或ICA重度狭窄或闭塞患者中4例脑血流灌注未见显著异常改变,36例患者TTP和MTT均发现与临床症状相对应的灌注延迟区,病变侧MTT(7.18±1.34)s、TIP(19.65±1.81)s与健侧MTT(5.22±1.14)s、TTP(17.62±1.65)s比较,差异有统计学意义(χ2值分别为30.833、25.817,P值均〈0.017);CBV、CBF未见明显异常。15例双侧MCA或ICA重度狭窄或闭塞患者,5例责任病灶侧与非责任病灶侧比较,脑血流灌注未见明显差异。10例责任病灶侧与非责任病灶侧比较,可见明显的脑血流灌注异常区,TTP和MTF较非责任病灶侧延迟,责任病灶侧CBF(42.85±6.09)ml·100g^-1·min^-1、CBV(2.63±0.42)ml·100g^-1、MTT(11.27±1.43)s、TFP(21.07±1.44)s和对照组CBF(71.20±6.30)ml·100g^-1·min^-1、CBV(2.29±0.15)ml·100g^-1、MTT(3.38±0.61)s、TTP(17.64±1.70)s比较,差异具有统计学意义(χ2值分别为17.314、5.913、17.334、13.834,P值均〈0.017)。应用容积穿梭扫描模式获得80mm动态Willis环4D-CTA图像,27例单侧MCA重度狭窄或闭塞患者中右侧MCA狭窄患者13例,左侧MCA狭窄患者9例;单侧MCA闭塞患者5例,其中右侧1例,左侧4例。9例双侧MCA重度狭窄或闭塞患者dD—CTA图像显示双侧MCA狭窄。4D—CTA图像与常规CTA、DSA显示Willis环血管Objective To evaluate the 80 mm volume shuttle cerebral CT peffusion(CTP) and 4D- CT angiography (CTA) in patients with stenosis or occlusion in Willis circle. Methods Conventional cerebral plain CT, 80 mm CTP and dynamic 4D-CTA were performed in 55 patients with unilateral MCA/ ICA stenosis or occlusion. The parameter maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTY) and time to peak (TFP) were analyzed. Meanwhile dynamic 4D-CTA images were also obtained. The significance of the differences of CBF, CBV, MTT and TTP between the affected side and the eontralatcral side was assessed using K Independent Samples analysis. Results In 40 patients with unilateral stenosis or occlusion of MCA/ICA, CTP was found abnormal in 36 patients. MTT and TTP of affected side [ (7.18 ±1.34), ( 19. 65 ± 1.81 ) s] were significantly prolonged compared to contralateral side [ (5.22 ± 1.14) s, ( 17.62 ± 1.65 ) s,χ2 = 30. 833,25. 817,P 〈 0. 017 ]. Centrum ovale or parietal lobe isehemic lesions were observed in 16 patients on CTP. In 15 patients with bilateral stenosis or occlusion of MCA/ICA, CTP was observed abnormal in 10 patients. CBF, CBV, MTT and TTP of affected side [(42.85 ±6.09) ml. 100g^-1·min^-1, (2.63 +0.42) ml·100 g^-1, (11.27 ±1.43) s, (21.07 ± 1.44) s)] were significantly different from those of eontralateral side [ (71.20 ± 6. 30) ml·100g^-1·min^-1, (2.29±0.15) ml·100 g^-1, (3.38 ±0.61) s,(17.64±1.70) s (χ2 =17.314, 5. 913,17. 334,13. 834,P 〈0. 017)]. On 4D-CTA covering 80 mm (0. 625 mm ×128), unilateral stenosis of MCA were observed in 22 patients ( 13 right MCA and 9 left MCA) , unilateral occlusion were observed in 5 patients ( 1 right MCA and 4 left MCA) and bilateral MCA stenosis/occlusion were observed in 9 patients. 4D-CTA covering Willis cycle can display stenosis/occlsion of MCA as same as conventional CTA and DSA. Conclusion 80 mm volume shuttle CTP and 4D-CTA p
关 键 词:大脑中动脉 颈内动脉 体层摄影术 X线计算机 血管造影术
分 类 号:R743.3[医药卫生—神经病学与精神病学]
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