癫痫患者T淋巴细胞亚群和泌乳素的测定  

Measurement of T lymphocyte subsets and prolactin in epileptic patients

作　　者：方桂远[1] 王建平[1] 王左生[1] 

机构地区：[1]河南医科大学第一附属医院神经内科

出　　处：《河南医科大学学报》1998年第4期82-84,共3页Journal of Henan Medical University

摘　　要：为探讨神经内分泌免疫调节功能变化在癫痫发病中的作用，采用放射免疫法和ＡＰＡＡＰ法对４６例癫痫患者和３０例健康对照组血清泌乳素（ＰＲＬ）及外周血Ｔ淋巴细胞亚群进行了检测。结果显示：癫痫患者ＣＤ４细胞及ＣＤ４／ＣＤ８比值明显低于对照组（Ｐ＜００１，Ｐ＜０００１）；ＣＤ８细胞和ＰＲＬ含量显著高于对照组（Ｐ＜０００１，Ｐ＜００１），且上述指标的改变与癫痫的发作频率有关；ＰＲＬ与ＣＤ４／ＣＤ８之间呈显著负相关。In order to study the effect of changes of neuroendocrineimmune regulating function in the pathogenesis of epilepsy,The levels of serum prolactin(PRL) and peripheral blood T lymphocyte subsets were measured by radioimmunoassay and APAAP method in 46 patiens with epilepsy and 30 normal controls.The results showed that the levels of CD 4 cells and the ratio of CD 4/CD 8 were significantly lower ( P <0.01～0.001),While the levels of CD 8 cells and PRL were much higher ( P <0.01～0.01) in epileptic patients than in normal controls.Futhermore,all the changes were related to the frequency of seizure,and significant negative correlation was found between PRL and CD 4/CD 8( r =-0.356 P <0.05).The findings suggest that the abnormlity of neuroendocrineimmune regulating function may play an important role in the pathogenesis of epilpsy.

关 键 词：癫痫 T细胞亚群 泌乳素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]