眼轮匝肌痉挛的病因与治疗方法探讨  

Cause and treatment of blepharospasm

作　　者：李慎乐[1] 宋秀君[1] 刘好文[1] 高洪全 

机构地区：[1]河北医科大学第三医院眼科

出　　处：《中国实用眼科杂志》1998年第12期726-728,共3页Chinese Journal of Practical Ophthalmology

摘　　要：为探讨单侧眼轮匝肌痉挛的病因及治疗方法，对１８２例患者观察了临床症状、体征，进行了Ａ型肉毒杆菌毒素治疗；３６例作了肌电图检查，１５例作了脑干磁共振血管成像检查（ＭＲＡ）。结果：１８２例眼轮匝肌痉挛者在数月后１７６例扩展致同侧全部面肌，Ａ型肉毒毒素治疗有效率为９４％，半年后复发率为８６％；肌电图检查患侧均出现自发性动作电位；脑干ＭＲＡ检查１５例患者中，１４例出现血管变异。结论：眼轮匝肌痉挛的病因与脑干血管变异，压迫面神经根出脑干处有关；Ａ型肉毒毒素治疗有效率９４％。Objective:To investigate the cause and therapeutic methods for blepharospasm.Methods:All the 182 patients were treated with botulinum A toxin through multifocal injection,EMG of facial muscles were performed in 36 patients and MRA in 15 patients.Results:Symptoms extended to all of the epilateral facial muscles a few months after onset in 176 patients.94% of the patients were relieved of symptoms after treatment,but 81% of patients relapsed half a year later.EMG showed spontaneous action potential in the 36 examed patients.MRA demonstrated vascular variation in 14 patients.Conclusion:The cause of blepharospasm is related to vascular variation which resulted in the compression of facial nerve.Treatment with botulinum A toxin is a effective method.

关 键 词：眼轮匝肌痉挛 A型肉毒毒素 病因 治疗 

分 类 号：R777.405[医药卫生—眼科]