中药六味安消联合左氧氟沙星根除幽门螺杆菌疗效观察  

The clinical observation for eradication of Helicobacter pylori with traditional medicine liuweianxiao and levofloxacin

作　　者：任一鸣 朱彩虹[1,2] 陈健华 阴爱华[1,2] 

机构地区：[1]扬州大学第四临床医院,226010 [2]南通瑞慈医院消化内科

出　　处：《中国实用医药》2010年第8期17-18,共2页China Practical Medicine

摘　　要：目的观察中药六味安消联合左氧氟沙星方案根除Hp的疗效。方法选择Hp阳性慢性胃炎250例,随机分为A组128例和B组122例,A组口服埃索美拉唑20mg加左氧氟沙星200mg,2次/d,1周,六味安消胶囊2.0g,3次/d,2周。B组口服埃索美拉唑片20mg加阿莫西林分散片1g加克拉霉素500mg,2次/d,1周。疗程结束1个月后行14C尿素呼气验检测Hp。结果A组和B组HP根除率分别为84.2%和73.0%,差异有显著性(P>0.05);A组和B组临床有效率分别为97.5%和94.8%,差异无显著性(P>0.05)。结论六味安消联合左氧氟沙星疗法比传统标准三联疗法的Hp根除率高,且与传统三联临床疗效相当,可作为根除Hp的治疗方案之一。Objective To investigate the efficacy of eradication of Helicobacter pylori（H pylori） with traditional medicine LiuWeiAnXiao and levofloxacin.Methods A total of 250 H pylori positive patients suffering from chronic gastritis were randomly allocated into two groups.Group A 128 patients received esomeprazole 20 mg ＋ levofloxacin200 mg,twice daily for 1 wk,LiuWeiAnXiao 2 g,three times daily,for 2 wk.group B 122 patients received esomeprazole 20 mg ＋ amoxicillin 1 g ＋ clarithromycin 500 mg,twice daily for 1 wk. H pylori status was assessed 4 weeks after the end of treatment by 14C urea breath test.Results H prior eradication rates were 84.2% in group A and 73.0% in group B,respectively,and the difference was significant （P〈0.05）.The total effective rates were 97.5% and 94.8% in two groups,respectively,and the difference was not significant （P〉0.05）.Conclusion The therapy with LiuWeiAnXiao and levofloxacin has a higher H prior eradication rates than traditional trigeminy therapy,and a same clinic effective to traditional trigeminy therapy.it is a feasible H pylori eradication regimen.

关 键 词：六味安消 左氧氟沙星 幽门螺杆菌 

分 类 号：R573[医药卫生—消化系统]