多发性肌炎/皮肌炎71例临床分析  

Clinical Analysis of 71 patients with Polymyositis/Dermatomyositis

作　　者：环文英[1] 杨霖[2] 

机构地区：[1]新疆克拉玛依市中心医院肾病风湿科,834000 [2]新疆克拉玛依市中心医院放射介入科,834000

出　　处：《中国实用医药》2010年第9期17-18,共2页China Practical Medicine

摘　　要：目的探讨多发性肌炎(PM)和皮肌炎(DM)患者的临床特点,以利临床诊断、指导治疗及判断预后。方法回顾性分析71例PM和DM患者的临床表现、肌酶水平、肌电图、肌活检以及转归,并对PM和DM进行分析比较。结果PM首发症状以发热肌痛、近端肌无力多见,DM则皮疹为首发症状。PM患者出现肌酶LDH,AST升高明显高于DM组患者,ILD在DM中发生率高于PM的,其差异具有统计学意义。PM的病理改变主要表现为散在肌纤维萎缩;DM以束周萎缩多见。影响预后的主要因素年龄、肺部感染,肿瘤有关。结论多发性肌炎和皮肌炎的临床特征及病理各有不同。Objective To explore the clinical features of patients with polymyositis（PM）and dermatomyositis（DM）to provide evidence for clinical diagnosis,treatment and prognostic evaluation.Methods Data of 71 eases of PM/DM concerning the initial symptoms,subsequent manifestations,muscle enzymes,eleetromyogram,muscle biopsy and prognosis were analyzed retrospectively and compared.Results Patients with PM were more likely to have fever,myalgia and muscle weakness at the onset,while skin lesions were the initial signs in most of DM patients irrespective of duration of the disease.The elevation of muscle enzymes was more common in PM compared with DM,and the changes in CK among PM/DM patients were of statistical significance before and after treatment（P0.05）.The pathological study showed diffuse muscle fiber atrophy predominating in PM and perimysium atrophy in DM.Age and pulmonary infection were important factors related to prognosis.Conclusion Differences in the clinical features and pathology between PM and DM is noted by this study.

关 键 词：多发性肌炎 皮肌炎 临床分析 

分 类 号：R746.5[医药卫生—神经病学与精神病学] R593.26[医药卫生—临床医学]