四甲基吡嗪多元醇及其乙酸酯的合成  

Synthesis of Polyols of Tetramethylpyrazine and Their Acetates

作　　者：秦凯[1] 李伟[1] 崔小兵[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210029

出　　处：《合成化学》2010年第2期251-253,共3页Chinese Journal of Synthetic Chemistry

基　　金：江苏省自然科学基金资助项目(BK2008454);南京中医药大学科技创新风险基金资助项目(CX200802)

摘　　要：四甲基吡嗪经溴代和酯化反应得到2,3,5-三乙酰氧甲基-6-甲基吡嗪(4)和2,3,5,6-四乙酰氧甲基吡嗪(5);4和5分别经水解得2,3,5-三羟甲基-6-甲基吡嗪和2,3,5,6-四羟甲基吡嗪。其结构经UV,1H NMR,13C NMR,IR和MS表征。2,3,5-triacetoxymethyl-6-methylpyrazine and 2,3,5,6-tetracetoxymethylpyrazine were synthesized from tetramethylpyrazine by bromination and esterification, then were hydrolyzed into 2,3,5-trihydroxymethyl-6-methylpyrazine and 2,3,5,6-tetrahydroxymethylpyrazine. The structures were confirmed by UV, 1^H NMR, 13^C NMR, IR and MS.

关 键 词：四甲基吡嗪 2  3  5-三乙酰氧甲基-6-甲基吡嗪 2 3 5  6-四乙酰氧甲基吡嗪 2  3  5-三羟甲基-6-甲基吡嗪 2  3  5  6-四羟甲基吡嗪 合成 

分 类 号：O626.425[理学—有机化学] R914.5[理学—化学]