动态检测乳腺癌患者外周血中CK19表达的临床研究  

The significance of detecting dynamically the expression of CK19 in peripheral blood of patients with breast cancer

作　　者：张月君[1] 王本忠[2] 张敬杰[2] 王劲[2] 

机构地区：[1]滁州市第一人民医院外四科,239000 [2]安徽医科大学第一附属医院乳腺外科,合肥230022

出　　处：《安徽医学》2010年第3期224-226,共3页Anhui Medical Journal

摘　　要：目的动态检测乳腺癌患者外周血细胞角蛋白19(cytokeratin 19,CK19)的表达并探讨其临床意义。方法应用流式细胞术(flow cytometry,FCM)动态检测32例乳腺癌、10例乳腺良性疾病及10例健康人外周血CK19的表达。结果32例乳腺癌患者外周血CK19阳性的总表达率为29.73%;外周血CK19的表达与TNM分期呈显著相关(P<0.05);与肿瘤大小、淋巴结有无转移、HER-2、ER、PR的表达均无相关性(P>0.05);IV期与I、II、III期之间有统计学意义。CK19表达预测远处转移敏感性高达100%,特异性为96.3%;10例良性患者及10例健康人外周血均无CK19表达。结论乳腺癌患者外周血CK19可以作为检测乳腺癌远处转移的敏感特异性指标。Objective To observe dynamically cytokeratin 19（CK19） expression in peripheral blood of breast cancer patients and evaluate its clinical significance.Methods CK19 in peripheral blood of 37 cases of breast cancer,10 cases of benign process in breast,and 10 healthy peoples was detected dynamically by flow cytomety（FCM）.Results The positive rate of CK19 in 32 breast cancer patients was 29.73%;CK19 expression was significantly related with TNM staging（P〈0.05）;but not with the tumor size,lymph node metastasis,HER-2,ER and PR expression（P〉0.05）;CK19 expression between stage Ⅳ and stage I、II、III had significant deviation.The sensitivity and specificity of ck19 expression for metastasis were 100% and 96.3%.Conclusion CK19 in peripheral blood can be detected as a sensitive-specific indicator for breast cancer metastasis.

关 键 词：流式细胞术 乳腺癌 细胞角蛋的19 

分 类 号：R737.9[医药卫生—肿瘤]