COX-1在卵巢癌组织中的表达及其意义  

Expression of cyclooxygenase-1 in ovarian cancer and its significance

作　　者：吴琼[1,2] 卞丽红[1] 胡晨明[1] 杨瑛[1] 李亚里[2] 

机构地区：[1]解放军307医院妇科,北京100071 [2]解放军总医院妇产科,北京100853

出　　处：《军事医学科学院院刊》2010年第1期58-60,共3页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的探讨环氧化酶-1(COX-1)在卵巢癌组织中的表达及其意义。方法应用免疫组化SP法检测37例卵巢癌和31例卵巢囊肿组织中COX-1和CA125蛋白的表达;应用ELISA法检测40例卵巢癌和31例卵巢囊肿以及60例正常体检者血清中COX-1和CA125的浓度。结果COX-1、CA125在卵巢癌组织的表达率分别为78%和57%,在卵巢囊肿的阳性表达率仅为7%和3%;卵巢癌患者血清COX-1、CA125的阳性率分别为65%和93%。结论COX-1蛋白表达可作为卵巢癌的辅助诊断指标。Objective To explore the expression of cyclooxygenase-1 in ovarian cancer and its significance.Methods Expression of COX-1 and CA125 was detected by immunohistochemistry in 37 cases of ovarian cancer and 31 cases of ovarian cyst.The serum level of COX-1 and CA125 was tested in 40 cases of ovarian cancer and 31 cases of ovarian cyst and 60 healthy volunteers by ELISA.Results The positive expression of COX-1 and CA125 was 78% and 57% in ovarian cancer and 3% and 7% in ovarian cyst,respectively.The expression of COX-1 and CA125 was 65% and 93% at the serum level.Conclusion Expression of COX-1 could act as an auxiliary diagnostic criterion in ovarian carcinoma.

关 键 词：COX-1 卵巢癌 蛋白表达 

分 类 号：R737.31[医药卫生—肿瘤]