10种中成药体外抗流感病毒活性研究  

In vitro anti-influenza virus activity of 10 traditional Chinese medicines

作　　者：何维英[1] 高荣梅[1] 李兴琼[1] 蒋建东[1] 李玉环[1] 

机构地区：[1]中国医学科学院、北京协和医学院医药生物技术研究所,北京100050

出　　处：《药学学报》2010年第3期395-398,共4页Acta Pharmaceutica Sinica

基　　金：科技部甲型H1N1流感联防联控应急科研项目

摘　　要：流感是一种高发病率和高死亡率的上呼吸道传染病,我国是流感高发区。国际上预防与治疗流感的主要措施是疫苗接种和抗病毒化学药物治疗。除此之外我国临床上还利用传统中药进行抗流感病毒治疗。本研究采用细胞病变(CPE)法,对10种中成药进行体外抗流感病毒活性检测。厂家H生产的清热解毒口服液体外对A/广东罗湖/219/2006(H1N1)具有较强的抑制活性;银黄口服液对A/汉防/359/95和A/粤防/243/72,厂家G生产的清开灵口服液对A/济防/15/90,厂家H生产的清热解毒口服液对A/济防/15/90、A/粤防/243/72和B/深圳/155/2005具有较强的抑制活性。Influenza virus is a virus causing upper respiratory tract infection disease with high morbidity and mortality. China is considered as an area with high rate of influenza morbidity. Prevention and treatment of influenza currently rely on vaccines and antiviral agents in the world. In addition, traditional Chinese medicines also have been used in clinical for influenza therapy. In vitro anti-influenza virus activities of 10 traditional Chinese medicines were studied by cytopathic effect （CPE）. Qingre Jiedu oral liquid （factory H） had strong antiviral activity against influenza virus A/Guangdong Luohu/219/2006 （H1N1）; Yinhuang oral liquid had strong antiviral activity against influenza virus A/Hanfang/359/95 and A/Yuefang/243/72 （H3N2）. Qingkailing oral liquid （factory G） had strong antiviral activity against influenza virus A/Jifang/15/90 （H3N2）. Qingre Jiedu oral liquid （factory H） had strong antiviral activity against influenza virus A/Jifang/15/90, A/Yuefang/243/72 （H3N2） and virus B.

关 键 词：中成药 抗流感病毒 体外 细胞病变法 

分 类 号：R965[医药卫生—药理学]