血清IL-10水平与胃窦癌恶病质的关系  

Association of cytokine IL-10 levels with cachexia from patients with low-third gastric cancer

作　　者：李春伟[1] 孙风波[1] 张佃良[1] 郑红梅[1] 宋波 

机构地区：[1]青岛大学医学院附属医院普通外科,山东青岛266003 [2]烟台山医院急诊科,山东烟台264000

出　　处：《肠外与肠内营养》2010年第2期69-71,共3页Parenteral & Enteral Nutrition

基　　金：山东省自然科学基金(Y2006C20);山东省科学技术发展计划(2008GG30002034)资助

摘　　要：目的:探讨胃窦癌病人血清细胞因子IL-10水平与发生恶病质的关系。方法:采用放射免疫法检测135例正常健康人(对照组)和150例胃窦癌病人的血清IL-10水平。结果:胃窦癌病人血清IL-10水平较对照组显著升高(P<0.01),并且血清IL-10水平胃窦癌Ⅲ、Ⅳ期明显高于Ⅰ、Ⅱ期(P<0.01)。胃窦癌恶病质的病人血清IL-10水平较非恶病质病人显著升高(P<0.01)。结论:血清IL-10水平与胃窦癌病人恶病质的发生具有相关性。Objective：To explore the association of the serum levels of cytokine IL-10 with the occurrence of cachexia from patients with low-third gastric cancer. Methods： Radioimmunoassay was used to examine the serum levels of IL-10 in 150 patients with low-third gastric cancer and 135 healthy controls. Results： The serum levels of IL-10 were significantly higher in patients with low-third gastric cancer than controls（Z=-11.862, P0.01）. The serum levels of IL-10 were significantly higher in patients with low-third gastric cancer of clinical stageⅢ/Ⅳ than those with clinical stageⅠ/Ⅱ（Z=-10.028, P0.01）. The serum levels of IL-10 were significantly higher in patients with cachexia than those without（Z=-10.369, P0.01）. Logistic regression analysis showed that IL-10 was associated with odds ratios of 1.599 （95%CI：1.299-1.870, P0.01） for cachexia. Conclusion： The serum levels of IL-10 are possibly associated with the occurrence of cachexia from patients with low-third gastric cancer.

关 键 词：细胞因子 胃窦癌 恶病质 

分 类 号：R735.2[医药卫生—肿瘤]