创伤性脑损伤动物模型及其实验治疗学应用  

Animal models for traumatic brain injury and its application in experimental therapeutics

作　　者：顾兵[1] 金建波[2] 孟玮[1] 李玉萍[1] 余日跃[2] 

机构地区：[1]江西科技师范学院生命科学院,江西南昌330013 [2]江西中医学院,江西南昌330006

出　　处：《中国药理学通报》2010年第3期285-289,共5页Chinese Pharmacological Bulletin

基　　金：江西省自然科学基金资助项目(No2007GQY1578);江西省教育厅科技计划资助项目(NoGJJ10244);江西科技师范学院校级课题(NoKY2008ZY04)

摘　　要：创伤性脑损伤(traumatic brain injury,TBI),亦称颅脑损伤或头部外伤,专指由外伤引起的脑组织损害。TBI发生机制以及神经损伤后的修复治疗是当前脑研究的热点问题。动物模型的复制对开展TBI的实验治疗学研究起了巨大的推动作用。该文就国内外已经建立的撞击脑损伤、非撞击加速脑损伤和爆炸冲击波致脑外伤三类动物模型的进展作系统综述,同时列举这些模型在实验治疗学上的应用,为神经保护药物的药效学筛选提供科学指导。Traumatic brain injury（TBI）,also known as intracranial injury or head trauma,specifically refers to the brain tissue damage caused by trauma.Currently the mechanism of TBI and repair therapy after nerve injury become a hotspot in brain research.Duplicating animal models plays a significant role in promoting experimental therapeutics of TBI.This review systematically describes the progress in animal models for TBI including impact brain injury,nonimpact acceleration head injury and blast（explosion）wave-induced neurotrauma,which have been established at home and abroad.Based upon the aforementioned models,some relevant applications in experimental therapeutics are simultaneously enumerated.Hopefully all these information provides scientific guidance for the pharmacodynamic screening of potential neuroprotective drugs.

关 键 词：创伤性脑损伤 动物模型 撞击脑损伤模型 非撞击加速脑损伤模型 爆炸冲击波致脑外伤模型 实验治疗学 

分 类 号：R-05[医药卫生] R363.332