转录因子Sp1与肿瘤关系研究的新进展  

Research progress on relationship between transcription factor Sp1 and tumor

作　　者：白雪[1] 邓红[1] 

机构地区：[1]浙江大学医学院病理学教研室,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2010年第2期215-220,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省自然科学基金资助项目(Y207308);浙江省教育厅科研基金资助项目(20070132)

摘　　要：Sp1参与了细胞的生长和分化等重要的生命过程,是目前研究极为广泛和系统的转录因子之一。在肿瘤的生长和转移过程中,Sp1可以通过调控癌基因、抑癌基因、细胞周期调控分子和生长相关信号转导通路、血管生成相关因子和细胞的凋亡过程,对各型肿瘤细胞产生重要影响。Sp1的表达水平和活性均受到严格的调控,具体机制包括对Sp1蛋白本身的修饰以及其它分子对Sp1的调控作用等。以Sp1作为靶点的新的肿瘤治疗方法,将会对临床肿瘤化疗策略产生深远的影响。Sp1 is a ubiquitous nuclear factor that plays a key role in maintaining basal transcription of ＇house-keeping＇ genes.It has been demonstrated that Sp1 is involved in many cellular process,e.g.cell growth and differentiation.Sp1 plays an extremely important role in growth and metastasis of many tumors by regulating oncogenes,tumor suppressor genes,cell cycle control molecules,growth-related signal transductions,angiogenesis-related factors,as well as apoptosis.The expression of Sp1 and its activity are strictly regulated.Mechanisms include the modulation of Sp1 and interactions between Sp1 and other molecules.New treatment with Sp1 as the target will bring profound impacts on the strategy of clinical chemotherapy of tumor.

关 键 词：肿瘤 转录因子 Sp1 SP1 综述[文献类型] 

分 类 号：R730.2[医药卫生—肿瘤]