口腔鳞癌中微淋巴管密度的检测及其临床意义  

Detection of microlymphatic vessels density in oral squamous cell carcinoma

作　　者：黄元清 宋宇峰[2] 张建国 

机构地区：[1]岳阳市二人民医院口腔外科,414000 [2]贵阳医学院附属医院口腔颌面外科

出　　处：《实用口腔医学杂志》2010年第2期202-204,共3页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:30660200);贵州省优秀科技教育人才省长专项基金(编号:2005-160)

摘　　要：目的:探讨淋巴管生成在口腔鳞癌中的作用。方法:对14例正常口腔黏膜组织、40例口腔鳞癌组织标本,应用免疫双重组织化学染色区分血管和淋巴管,人工记数微淋巴管密度(MLVD),分析其与颈淋巴结转移的关系。结果:40例口腔鳞癌组织中MLVD显著高于14例正常口腔黏膜组织(P<0.01),口腔鳞癌组织中MLVD与肿瘤的TNM分期及其淋巴结转移密切相关(P<0.01)。结论:淋巴管生成可能参与了口腔鳞癌的生长、浸润及转移,提示测定口腔鳞癌中MLVD对评估其淋巴结转移和预后判断可能具有重要意义。Objective： To approach the role of lymphangiogenesis in oral squamous cell carcinoma（OSCC）. Methods： Immunohistochemical double staining technique was utilized to distinguish lymphatic vessels from blood vessels. MLVD was determined by manual counting to analyze the relationship with lymph node metastasis. Results： MLVD was significantly higher in 40 OSCC than 14 normal mucosa（ P 〈0.01 ）. MLVD in OSCC showed a statistically significant relationship with regional lymph node metastasis, depth of invasion（ P 〈 0.01 ）. Conclusion： Lymphangiogenesis might occur in growth, infiltration and metastasis of OSCC. Detection of MLVD in OSCC might be important to evaluate tumor metastasis and judge prognosis.

关 键 词：口腔鳞癌 淋巴结转移 微淋巴管密度 淋巴管生成 

分 类 号：R739.8[医药卫生—肿瘤]