口腔颌面部肉瘤微血管密度及VEGF和bFGF的表达  

A study on microvessel density,VEGF and bFGF in oromaxillofacial sarcoma

作　　者：王彦敏[1] 张杰英[2] 董福生[3] 安志毅[1] 

机构地区：[1]石家庄第三医院口腔科,050011 [2]河北医科大学附属第二医院病理科 [3]河北医科大学口腔医院

出　　处：《实用口腔医学杂志》2010年第2期217-219,共3页Journal of Practical Stomatology

摘　　要：目的:探讨血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)与微血管密度(MVD)在口腔颌面部肉瘤的表达及与相互关系。方法:对经病理证实口腔颌面部肉瘤57例切片,采用免疫组化SP法检测VEGF、bFGF、MVD在瘤组织中的表达,对其相互间关系进统计学分析。结果:VEGF、bFGF阳性率分别为82.4%、80.7%,MVD中位数为36.24±20.48,三者明显差异于良性病变(P<0.05)。VEGF、bFGF表达和MVD相关(P<0.05)。结论:MVD、bFGF和VEGF三者检测结果对深入探讨肉瘤血行转移形成有参考价值。Objective ：To explore the role of MVD, bFGF and VEGF in OMFS and the relationship between them. Methods： Immu- nochemistry streptavidin peroxidase method was used to detect the MVD and the bFGF, VEGF expressions in 57 cases of OMFS sam- pies. Results： MVD, bFGF and VEGF expressions were different between OMFS and benign. The close correlations were found among the expressions of VEGF, bFGF and MVD. Conclusion ： The expressions of VEGF and bFGF are associated with MVD which indicated that VEGF and bFGF may play important roles in angiogenesis.

关 键 词：口腔颌面部肉瘤 血管内皮生长因子 碱性成纤维细胞生长因子 微血管密度 免疫组化 

分 类 号：R739.8[医药卫生—肿瘤]