分子影像标记物叶酸受体α在胰腺癌中的表达及意义  

Expression of molealar imaging marker folate receptor alpha in pancreatic cancer and its significance

作　　者：郑洪民[1] 

机构地区：[1]黑龙江省医院放射线科,哈尔滨150036

出　　处：《山东大学学报（医学版）》2010年第3期83-85,共3页Journal of Shandong University:Health Sciences

摘　　要：目的观察叶酸受体α(folate receptor alpha,FOLR1)在胰腺癌中的表达水平,为叶酸受体α靶向性分子显像技术的建立提供依据。方法采用免疫印迹和免疫组织化学法检测叶酸受体α在胰腺癌、正常胰腺、癌旁和慢性胰腺炎症组织的表达,并评价其表达水平与胰腺癌临床病理学指标的关系。结果叶酸受体α在94.7%(72/76)的胰腺癌中阳性表达,且表达水平与肿瘤转移相关,而在正常胰腺中无表达。结论以叶酸受体α为靶点的分子影像技术在胰腺癌的诊断中可能具有良好的应用价值。Objective To observe expression of folate receptor α in pancreatic cancer in order to evaluate its utility as a molecular imaging target for pancreatic cancer magnetic resonance（MR） diagnosis.Methods Folate receptor α expression was evaluated by immunoblot and immunohistochemistry in pancreatic cancer,normal pancreatic tissues,paratumoral and para-tumoral tissues,and the relationship between folate receptor α expression and clinicopathological parameters was also analyzed.Results Folate receptor α was overexpressed in most pancreatic cancer tissues（97.4%,72/76）,but not in the normal controls.Furthermore,up-regulation of folate receptor α was associated with pancreatic cancer metastasis.Conclusion Folate-based contrast agents might be helpful in pancreatic cancer MR imaging.

关 键 词：胰腺肿瘤 分子影像 叶酸受体 

分 类 号：R730.1[医药卫生—肿瘤]