乳腺癌中HGF及其受体c-met的表达与淋巴管生成及淋巴道转移的关系  

Expressions of hepatocyte growth factor and its receptor c-met in breast carcinoma and their relationship to lymphangiogenesis and lymphatic metastasis

作　　者：王婧男[1] 张楠[2] 赵建强[2] 高爱琴[3] 林文俐[3] 孙玉萍[2] 

机构地区：[1]山东省医学科学院基础医学研究所,济南250062 [2]山东大学附属济南市中心医院肿瘤科,济南250013 [3]山东大学医学院,济南250012

出　　处：《山东大学学报（医学版）》2010年第3期90-93,共4页Journal of Shandong University:Health Sciences

基　　金：山东省自然科学基金资助课题(Q2006C03);济南市科技明星计划资助课题(济青科合字2007第1-115号)

摘　　要：目的检测肝细胞生长因子(HGF)及其受体c-met在乳腺癌中的表达,探讨其与乳腺癌淋巴管生成及淋巴道转移的关系。方法应用免疫组织化学SP法标记淋巴管,计数微淋巴管密度(LMVD),检测70例乳腺癌患者及22例乳腺良性肿瘤患者组织中HGF、c-met的表达,分析其表达情况与LMVD及临床病理参数之间的关系。结果HGF和c-met在乳腺癌组织中存在高表达,其阳性表达率(61.43%、80.00%)明显高于良性肿瘤(31.82%、45.45%),P均<0.05,癌组织中的LMVD明显高于良性肿瘤(秩和检验,U=366.00,P<0.05);HGF或c-met阳性表达的乳腺癌患者较阴性者有更高的LMVD[HGF:(17.00±5.23)vs(10.36±4.12),t=5.594,P<0.05;c-met:(15.64±5.50)vs(9.65±4.46),t=3.769,P<0.05],HGF、c-met的阳性表达与TNM分期、淋巴结转移显著相关(P均<0.05)。结论HGF及其受体c-met的表达可促进乳腺癌淋巴管的新生及淋巴道转移,相关抑制剂的研究将有可能成为预防和治疗乳腺癌淋巴道转移及远处转移的新方法。Objective To determine expressions of hepatocyte growth factor（HGF） and its receptor c-met,and to evaluate their relationship to lymphangiogenesis and lymphatic metastasis in breast carcinoma.Methods Applying the immunohistochemical SP method,lymphatic vessels and expressions of HGF and c-met were detected in 70 breast carcinomas and 22 mammary benign neoplasms.And the lymphatic micro-vessel density（LMVD） was counted.The relationship of HGF and c-met to LMVD and the clinicopathological features of breast carcinoma were then analyzed.Results HGF/c-met were highly expressed in breast carcinoma,and their expression positive rates were significantly higher than those in benign neoplasm（HGF：61.43% vs 31.82%,c-met：80.00% vs 45.45%,both P〈0.05）.The LMVD of breast carcinoma was significantly higher than that of benign neoplasm（using Rank Test,U=366.00,P〈0.05）.Higher LMVD was found in breast carcinoma with HGF-or c-met-positive expression than in that with negative expression[HGF：（17.00±5.23） vs（10.36±4.12）,t=5.594,P〈0.05;c-met：（15.64±5.50） vs（9.65±4.46）,t=3.769,P〈0.05].Expressions of HGF and c-met were positively correlated with TNM stage and lymph nodemetastasis（both P〈0.05）.Conclusion Over-expressions of HGF and c-met can promote breast carcinoma lymphangiogenesis and lymphatic metastasis.

关 键 词：乳腺肿瘤 肝细胞生长因子 受体 c-met 淋巴管生成 

分 类 号：R737.9[医药卫生—肿瘤]