非小细胞肺癌组织Survivin表达及其与预后的相关性  

Expression of Survivin and correlation between it and prognosis of NSCLC

作　　者：翁贤武[1] 张建海[1] 任哲[1] 梁诚之[1] 林培锋[1] 

机构地区：[1]温州医学院附属第三人民医院胸心外科,浙江瑞安325200

出　　处：《中华肿瘤防治杂志》2010年第3期198-200,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨Survivin在判断非小细胞肺癌(NSCLC)的病情及预后中的价值。方法:对NSCLC组织50例应用免疫组织化学染色法检测Survivin的表达,并分析其与各项临床因素以及预后的关系。结果:Survivin在NSCLC组织中表达的阳性率为78.0%(39/50);Survivin在NSCLC组织的表达状况与患者的性别、年龄、肿瘤分布、肿瘤直径、组织学分类、分化程度和p-TNM分期无关,P>0.05;生存率的单因素分析显示,Survivin的表达状况(P=0.035)、p-TNM分期(P=0.000)与患者的预后相关;生存率的多因素分析显示,Survivin的表达状况(P=0.027)、p-TNM分期(P=0.000)是影响患者预后的独立指标。结论:NSCLC患者术后生存率受Survivin表达、p-TNM分期等多种因素的影响。Survivin表达是影响患者预后的独立指标。OBJECTIVE：To detect the expression of the Survivin,a novel inhibitor gene of apoptosis,in NSCLC,then to evaluate the clinical significance.METHODS：The expression of Survivin was determined by means of immunohistochemistry in the cancer specimens of the 50 samples.Postoperative survival was univariately analyzed by the Kaplan-Meier method,and the difference was assessed by the Log-rank test.Multivariate analyses were performed by using the COX proportional hazards modeling.RESULTS：The expression rates of Survivin in NSCLC tissues was 78.0%（39/50）.Univariate analyses demonstrated that the survival rate of the 50 NSCLC patients was significantly affected by Survivin status （P=0.035） and p-TNM stages （P=0.000）,and not by sex,age,tumor distribution,diameter,histology type,differenition and p-TNM staging（P〉0.05）.Multivariate analyses （Cox proportional hazards modeling） revealed that Survivin status （P=0.027） and p-TNM stages （P=0.000） were independent prognostic factors of NSCLC patients.CONCLUSIONS：The survival rate of NSCLC patients is affected by such prognostic factors as Survivin status and p-TNM stages.Survivin status,p-TNM stagesare the two independent predictors of NSCLC patients.

关 键 词：癌 非小细胞肺 预后 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]