纵隔淋巴结清除范围对Ⅰ期非小细胞肺癌患者的影响  

Effect of extent of lymphadenectomy in stage Ⅰ non-small cell lung cancer patients

作　　者：陈豪[1] 黄国忠[1] 谢金标[1] 赵金树[1] 鲍德胜[1] 

机构地区：[1]莆田学院附属医院胸心外科,福建莆田351100

出　　处：《中华肿瘤防治杂志》2010年第3期213-214,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:比较不同纵隔淋巴结清除范围对Ⅰ期非小细胞肺癌(NSCLC)患者生存的影响。方法:回顾性分析97例手术切除的Ⅰ期NSCLC患者临床资料,比较纵隔淋巴结清除术(SML)与纵隔淋巴结采样术(LS)对于患者生存的影响。用Kaplan-Meier曲线及Log-rank检验进行生存分析和比较,并用Cox多因素回归分析了解与生存相关的因素。结果:行SML的患者(n=28)5年生存率优于行LS的患者(n=69;84.36%vs68.54%;P=0.025)。Cox多因素分析提示,行SML是影响患者预后的因素。结论:肺叶切除加上SML能提高Ⅰ期NSCLC患者的长期生存率,可列为NSCLC的规范性术式。OBJECTIVE：To validate the extent of lymphadenectomy on the survival of the patients with stage Ⅰ non-small cell lung cancer （NSCLC）.METHODS：A total of 97 patients who underwent complete surgical resection for stage Ⅰ NSCLC were reviewed retrospectively.The effects of systemic mediastinal lymphadenectomy（SML） and LS on survival of patients were compared.Kaplan-Meier curve and Log-rank check were used to analyze the survival rate,and the Cox multivariate analysis was used to analyze the survival-related factors.RESULTS：The 5-year survival rate for patients with systematic mediastinal lymphadenectomy （n=28） was 84.36% while patients with mediastinal lymph node sampling （n=69） was 68.54% （P=0.025）.The Cox multivariate analysis showed that SML significantly affected the overall survival.CONCLUSION：SML plus pulmonary lobectormy are important in patients with stageⅠnon-small cell lung cancer.

关 键 词：癌 非小细胞肺 淋巴结切除术 外科手术 

分 类 号：R734.2[医药卫生—肿瘤]