Girdin蛋白与肿瘤转移相关性的研究进展  

Advances of correlation between new protein Girdin and tumor metastasis

作　　者：王静[1] 谷峰[2] 马勇杰[1] 

机构地区：[1]天津医科大学附属肿瘤医院研究所中心实验室乳腺癌防治教育部重点实验室天津市"肿瘤防治"重点实验室,天津300060 [2]天津医科大学附属肿瘤医院乳腺病理研究室乳腺癌防治教育部重点实验室天津市"肿瘤防治"重点实验室,天津300060

出　　处：《中华肿瘤防治杂志》2010年第3期233-236,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家重点基础研究发展计划973项目子课题(2006CB705600);国家自然科学基金(30700253;30800355)

摘　　要：目的:总结国内外对Girdin的结构及功能方面的研究进展。方法:应用Medline及维普数据库,以"Girdin、actincytoskeleton和细胞迁移"等为关键词,检索1996-01-2009-09的相关文献,共检索到英文文献786条,中文文献30条。纳入标准:1)Girdin的结构及相关功能的研究。2)细胞迁移所涉及的骨架结构的改变机制的研究。3)细胞迁移和侵袭相关内容的研究。根据纳入标准,精选35篇文献,最后纳入分析25篇文献。结果:Girdin(又被命名为APE、GIV、HkRP1)是一种新发现的肌动蛋白结合蛋白,它能与Akt相互作用,在调节肌动蛋白的结构及促进肿瘤细胞的运动等方面具有重要作用,但其详细机制还不明确。结论:Girdin作为抗肿瘤转移的新靶点,为指导肿瘤的临床治疗提供新的思路。OBJECTIVE：To summarize the current articles about the structure and functions of girdin.METHODS：＂Girdin,actin cytoskeleton,cell migration＂ were searched as key words by Medline and VIP from 1996-01 to 2009-09.Totally 786 English papers and 30 Chinese papers were obtained.Choice criteria：1） the structure and functions of girdin;2） the mechanisms of the regulation of actin cytoskeleton in migration cells;3） the association of cell migration and metastasis with girdin.According to the choice criteria,35 papers were selected,and 25 papers were finally decided as references.RESULTS：Girdin （also named as APE,GIV,or HkRP1）,identified as a novel actin-binding protein is reported to interact with Akt,and affects the migration and invasion of cancer cells.However,the mechanisms of its tumor-suppressive effect have not been elucidated.CONCLUSION：Girdin,as a new target,will be considered in combination therapy for the prevention and treatment of cancer metastasis.

关 键 词：肌动蛋白类 肿瘤转移 综述文献 

分 类 号：R730.2[医药卫生—肿瘤]