Fas和Bax蛋白表达与食管鳞癌放疗敏感相关性的研究  

Relationships between expression levels of Fas and Bax proteins and radiosensitivity of esophageal squamous cell carcinoma

作　　者：叶柯[1] 葛红[1] 蒋月[1] 刘海龙[1] 马杰[2] 

机构地区：[1]河南省肿瘤医院放疗科,河南郑州450003 [2]河南省肿瘤医院病理科,河南郑州450003

出　　处：《中华肿瘤防治杂志》2010年第4期270-272,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：河南省科技厅科研课题重点科技攻关基金资助项目(05230303002)

摘　　要：目的:探讨Fas和Bax蛋白在食管鳞癌术前放疗前后的表达及其与放疗敏感性的关系。方法:采用免疫组化SP法检测56例放疗前胃镜活检标本及放疗后食管癌根治性切除术后标本Fas和Bax蛋白的表达水平。结果:放疗前后食管癌组织中Fas蛋白表达分别为0.47±0.23和0.61±0.17,差异有统计学意义,P<0.05;放疗前后食管癌组织中Bax蛋白表达为0.44±0.20和0.54±0.21,差异无统计学意义,P>0.05。放疗前后Fas和Bax蛋白表达呈正相关,P<0.05。放疗前Fas和Bax蛋白表达与放疗后X线分级呈负相关,P<0.05;而放疗后Fas和Bax蛋白表达与放疗后X线分级无明显相关性,P>0.05。结论:Fas和Bax蛋白是反映中晚期食管鳞癌肿瘤细胞的放射敏感性和判断术前放疗效果的重要指标。OBJECTIVE：To study the relationships between the expression levels of Fas and Bax before and after radiotherapy and radiosensitivity.METHODS：The expression levels of Fas and Bax in biopsy samples from all the patients before and after radiotherapy were detected with the SP immunohistochemistry method in biopsy samples from 56 patients.RESULTS：Before and after radiotherapy,the expression levels of Fas were 0.47±0.23 and 0.61±0.17,respectively（P0.05）,and the expression levels of Bax were 0.44±0.20 and 0.54±0.21,respectively（P0.05）.The correlation between the expression levels of Fas and Bax before and after radiotherapy was positive（P0.05）.The expression levels of Fas and Bax in biopsy samples before radiotherapy was positive to BM grades（P0.05）.However,the correlation between the expression levels of Fas and Bax after radiotherapy and BM grades of esophageal squamous cell carcinoma were negative（P0.05）.CONCLUSION：Fas and Bax proteins are the important parameters reflecting the radiosensitivity and predicting the radiotherapeutic effec of squamous cell carcinoma of esophagus.

关 键 词：食管肿瘤/病理学 癌 鳞状细胞/病理学 基因 Fas 基因 Bax 辐射耐受性 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]