复方甘草酸苷注射液治疗放射性肝病的临床研究  

Clinical trial of compound glycyrrhizin injection for the treatment of radiation-induced liver disease

作　　者：金璋[1] 陈增边[1] 曹辉[1] 沈洁[1] 

机构地区：[1]温州医学院定理临床学院放疗科,浙江温州325000

出　　处：《中国临床药理学杂志》2010年第3期183-185,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察复方甘草酸苷(肝保护剂)注射液治疗放射性肝病的疗效。方法对66例发生Ⅰ-Ⅱ级放射性肝病的原发性肝癌患者,随机分为治疗组和对照组,对照组采用甘利欣注射液联合目前通用的综合治疗措施。治疗组在此基础上,应用复方甘草酸苷注射液静脉滴注60～100mL.d-1,疗程为4周;疗程结束后,继续服用复方甘草酸苷片150mg.d-1,至16周。结果各项肝功能指标治疗总有效率,治疗组均优于对照组(P<0.05)。结论复方甘草酸苷注射液可有效降低放射性肝病患者的转氨酶、胆红素水平,且用药安全。Objective To evaluate the efficacy of compound glycyrrhizin injection for the treatment of radiation - induced liver disease. Methods Sixty - six patients with the first and the second class of radiation - induced liver impairment were randomly divided into the trial group and the control group. Diammonium glycyrrhizinate injection and comprehensive treatment were used in the control group. Compound glycyrrhizin injection and the comprehensive treatment were used in the trial group. Compound glycyrrhizin injection was administered intravenously with the dose 60 - 100 mL ·d^-1 , and the course of treatment was 4 weeks. After that, compound glycyrrhizin tablets were given with the dose 150 mg·d^-1 for another 12 weeks. Results The treatment efficacy rate of liver - function parameters of the trial group was much higher than that of the control group （P 〈 0.05 ）. Conclusion Compound glycyrrhizin injection was effective and safe in the treatment of the radiation - induced liver impairment.

关 键 词：放射性肝病/放射性肝损伤 三维适形放射治疗 复方甘草酸苷注射液 

分 类 号：R575.2[医药卫生—消化系统] R975.5[医药卫生—内科学]