真菌性角膜病在河南地区的流行病学研究  

Keratomycosis in Henan: Epidemiologic and microbiolcgic evaluation

作　　者：王丽娅[1] 王莉[2] 张月琴[1] 王爱民 王印其[1] 

机构地区：[1]河南省眼科研究所 [2]河南职工医学院 [3]延津眼科医院

出　　处：《中国全科医学》1998年第3期152-154,共3页Chinese General Practice

基　　金：河南省科委攻关计划资助

摘　　要：目的调查河南地区真菌性角膜病的发病情况、流行病学特点、危险因素、主要致病真菌等。为进一步深入细致的基础研究和临床治疗奠定基础。方法回顾性调查1990年7月～1998年1月收入我院病房的240例（240眼）真菌性角膜病患者。结果7年的统计资料表明，真菌性角膜病患病人数呈逐年上升趋势。发病高峰集中在每年的10～12月。中青年患者居多。患病前有明确外伤史（主要是植物外伤史）者占总患病人数的36％。88．8％的患者接受了手术治疗。主要致病真菌属依次为镰孢菌属（69％）、曲菌属（1．5％）和青霉属（9．4％）、茄病镰孢菌是最主要的致病菌种。结论真菌性角膜炎是严重致盲性眼病。要重视角膜植物性外伤的处理。眼局部不滥用皮质类固醇和抗生素。要加强对常见角膜致病真菌的基础和临床研究。Objective To investigate the demographic features, risk factors, and organisms incases of mycotic keratitis in Henan. Methods We retrospectively analyzed 240 cases (240 eyes) ofmycotic keratitis. Results Fusarium solani specie was the most frequent isolated (37. 5% ). Otherincluded fusarium moniliforme (18. 8% ), fusarium eguiseti (9. 4% ), aspergillus fumigatus (9. 4%), andpenicillium incplicatum Biourge (6. 3% ). A seasonal variation in the incidence of mycotic keratitisrevealed a peak incidence in the months from October to December. Trauma, especially vegetable matterin jury, was the most common predisposing factor (36% ). Of the patients with fungal keratitis, 15%(37 patients ) were treated with corticosteroids before the onset of keratitis. 18% (42 patients) weretreated with antiviral agents, and 58% (138 patients ) were treated with antibiotic. Conclusion Thisstudy highlights risk factors and organisms responsible for mycotic keratitis in Henan.

关 键 词：真菌性 角膜病 流行病学 

分 类 号：R772.210.1[医药卫生—眼科]