神经节细胞瘤致难治性癫痫的临床诊疗分析  

Diagnosis and treatment of intractable epilepsy caused by ganglioglioma

作　　者：闫晓明[1] 李勇杰[1] 张国君[1] 遇涛[1] 杜薇[1] 乔梁[1] 

机构地区：[1]首都医科大学北京宣武医院功能神经外科,北京功能神经外科研究所,北京100053

出　　处：《癫痫与神经电生理学杂志》2010年第1期9-12,共4页Journal of Epileptology and Electroneurophysiology(China)

基　　金：北京市自然科学基金资助（3051001）

摘　　要：目的：总结12例术后病理证实为神经节细胞瘤所致难治性癫痫患者的临床特点及手术治疗方法。方法：回顾2006年1月至2007年5月在北京宣武医院功能神经外科诊治的12例经病理证实为神经节细胞胶质瘤患者的临床资料，对其发作形式、影像学检查、脑电图表现和手术治疗措施等进行分析。结果：癫痫发作可以是神经节细胞瘤唯一的临床表现，MRI检查有相对特异性，视频脑电监测到的发作性电活动的起源部位均与影像学病灶同侧，且与病灶及周边相关。术后按Engel疗效评估标准：Ⅰ级10例，占83％；Ⅱ级2例，占17％。结论：皮层脑电监测下的致痫灶组织及周围异常脑电活动区切除术是治疗该病的有效手段。Objective：To analyze and summarize the clinical characteristics and surgical treatment of 12 patients with postoperational diagnosis of ganglioglioma leading to refractory epilepsy. Methods： Retrospective study was applied to analyze the clinical information of 12 cases with postoperational diagnosis of ganglioglioma from January 2006 to May 2007, who were treated at Beijing Institute of Functional Neurosurgery. The semiology, neuroimaging results,electroencephalography and surgical operations on the patients were analyzed. Results： Paroxysmal seizures could be the only clinical manisfestation of ganglioglioma. The MRI scan had relative specificity, and video-electroencephalography was consistent with neuroimaging results in lateralizing the epileptogenic zone, which was related to the ganglioglioma and surrounding areas. The clinical outcome of the 12 cases were shown as the following： Engel Class I took up 83% and Engel Class Ⅱ took up 17%. Conclusion： Surgical resection of the tumor and its surrounding issues with abnormal electroencephalogram activity guided by cortical electroencephalogram is an effiective method for treating ganglioglioma-induced epilepsy. G

关 键 词：神经节细胞瘤 难治性癫痂 脑电图(EEG) 磁共振成像(MRI) 痫灶定位 

分 类 号：R739.41[医药卫生—肿瘤] R742.1[医药卫生—临床医学]