分化抑制因子-1在大肠癌中的表达及临床意义  

The expression and clinical significance of Id-1 in colorectal carcinoma

作　　者：胡斌[1] 陈志康[1] 陈晋湘[1] 葛杰[1] 陈子华[1] 

机构地区：[1]中南大学湘雅医院普通外科,湖南长沙410008

出　　处：《现代生物医学进展》2010年第1期118-120,共3页Progress in Modern Biomedicine

摘　　要：目的:研究分化抑制因子-1(Id-1)在人大肠癌组织中的表达及其与临床病理特征的关系。方法:应用免疫组织化学方法(SP法)检测Id-1在56例大肠癌组织及56例远癌肠黏膜中的表达水平,并分析其与临床病理特征的关系。结果:在大肠癌组织中Id-1的过表达率为80.4%,在远癌肠粘膜中过表达率为12.5%,两组比较差异有统计学意义(P<0.01)。Id-1过表达与大肠癌Dukes分期及淋巴结转移有关(P<0.05),而与患者年龄、性别、肿瘤组织分化程度无关(P>0.05)。结论:Id-1过表达可能参与大肠癌演进,Id-1可作为判断大肠癌恶性程度和预后的指标。Objectives：To study the expression of inhibitor of differentiation/DNA binding（Id-1） in human colorectal carcinoma and its relation to clinicopathological characteristics.Methods：The expression of Id-1 in 56 cases of colorectal carcinoma and 56 cases of intestinal mucosa distant from the tumor were determined by immunohistochemical method（SP method）,and the relationship between the expression of Id-1 and the clinicopathological characteristics were analyzed.Results：The overexpression rates of Id-1 in colorectal carcinoma tissues and intestinal mucosa distant from the tumor were 80.4% and 12.5%,respectively.Compared colorectal carcinoma tissues with intestinal mucosa distant from the tumor,there was a significant difference（P0.01）.The overexpression of Id-1 in colorectal carcinoma was correlated with Dukes stages and lymph node metastasis（P0.05）,but not correlated with age,gender or grade of differentiation（P0.05）.Conclusions：The overexpression of Id-1 in colorectal carcinoma may be involved in the progression of colorectal carcinoma.It may be a good marker for monitoring the malignant degree and the prognosis of colorectal carcinoma.

关 键 词：大肠癌 分化抑制因子-1 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]