幽门螺杆菌感染与缺铁性贫血的关系  

The relationship between infection of helicobacter pylori and iron deficiency anemia

作　　者：朱爱萍[1] 方国全[1] 徐海涛[1] 张煌[1] 鲁恒珍 

机构地区：[1]安庆市第一人民医院血液科,安徽省安庆246001

出　　处：《中国基层医药》2010年第4期449-450,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨幽门螺杆菌（Hp）感染与缺铁性贫J缸（IDA）的关系，以及Hp相关IDA的治疗。方法分别统计40例IDA伴慢性胃炎与42例非IDA慢性胃炎两组Hp感染率。将36例Hp感染相关IDA随机分成两组，分别应用根除细菌加口服铁剂与单用铁剂方案治疗，检测治疗前后血液学指标，观察疗效。结果IDA伴慢性胃炎者Hp感染率为90％高于非IDA慢性胃炎者（70％），两者差异有统计学意义；Hp感染相关IDA患者接受根除细菌加铁剂治疗前后其Hb、血清铁、铁蛋白均显著增高，而单用铁剂组治疗前后血液学指标无显著变化。结论Hp感染与IDA可能有一定相关性，当IDA患者铁剂治疗效果不显著时宜考虑是否存在Hp相关IDA；根除Hp感染后对IDA有一定治疗作用。Objective To investigate the relationship between infection of helieobacter pylori（Hp） and iron deficiency anemia（IDA） and to explore effective clinical treatments for patients with Hp associated IDA . Method 1. The Hp infection ratio of 40 chronic gastritis with IDA and 42 patients without IDA were counted up respectively. 2. 36 patients with Hp-positive chronic gastritis were divided into two groups randomly. One group was treated by using Hp eradication therapy in conjunction with oral iron supplement and the other using iron supplement only. The hema- tological parameters before and after treatment are measured and the effectiveness of the treatment was evaluated. Re- sult The Hp infection ratio in chronic gastritis patients with IDA is higher than that in patients without IDA and the difference is significant. After Hp eradication therapy in conjunction with iron supplement Hb. serum iron and serum ferritin level in Hp associated IDA patients are increased significantly while that for patients treated by using iron sup- plement only have no significant improvement, Conclusion It appears that Hp infection may be related to IDA. When iron supplement treatment has no obvious effect to an IDA patient,it may suggest a case of Hp associated IDA. The i- ron supplement treatment has positive effects to IDA patients after Hp eradication.

关 键 词：贫血 缺铁性 螺杆菌 幽门 阿莫西林 亚铁化合物 

分 类 号：R573[医药卫生—消化系统]