Poly(ethylene glycol)-supported Piperazine——Synthesis and Application in Knoevenagel Condensation  

作　　者：WANG Cui-e JIN Jie ZHANG Min YU Shu-yan SHANG Yong-jia HU Jin-song 

机构地区：[1]College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids,Anhui Key Laboratory of Molecular Based Materials, Anhui Normal University, Wuhu 241000, P. R. China

出　　处：《Chemical Research in Chinese Universities》2010年第2期263-267,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.20872001);the Natural Science Foundation of Education Administration of Anhui Province,China(No.KJ2008A064)

摘　　要：A soluble, poly（ethylene glycol）-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acetoacetate in a homogeneous phase to afford the desired alkenes in good purity and yield with a facile work-up process. It was found that the polymer reagent could be repeatedly used at least four times without the too much loss of activity. The catalyst has shown a good activity, stability, and recycling capability.A soluble, poly（ethylene glycol）-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acetoacetate in a homogeneous phase to afford the desired alkenes in good purity and yield with a facile work-up process. It was found that the polymer reagent could be repeatedly used at least four times without the too much loss of activity. The catalyst has shown a good activity, stability, and recycling capability.

关 键 词：PIPERAZINE Polymer-supported catalyst Knoevenagel condensation 

分 类 号：O625.63[理学—有机化学] TQ223.162[理学—化学]