自体骨髓干细胞移植治疗晚期肝硬化的近期临床观察  

Transplantation of autologous bone marrow stem cells for the treatment of advanced liver cirrhosis

作　　者：邓元明[1] 张龙[1] 牟方胜[1] 王辉[2] 

机构地区：[1]重庆三峡中心医院放射科,重庆404000 [2]重庆三峡中心医院肝病中心

出　　处：《当代医学》2010年第5期40-41,共2页Contemporary Medicine

摘　　要：目的评价自体骨髓干细胞移植治疗肝炎后肝硬化的近期临床疗效。资料与方法回顾分析我院就诊的8例晚期肝硬化患者行自体骨髓干细胞移植后,患者乏力、纳差、腹胀等症状的改善情况及不良反应发生的情况,并于术后1月、3月复查肝功,了解肝功特别是总胆红素、白蛋白等变化情况。结果8例患者在肝动脉灌注过程中均很顺利,无明显不良不适;白蛋白较术前明显增高、总胆红素较前降低均有统计学意义。结论自体骨髓干细胞移植治疗晚期肝硬化近期效果较满意,其长期疗效有待进一步随访观察。Objective To observe the short-term clinical curative effect of transplantation of autologous bone marrow stem cells in the treatment of advanced liver cirrhosis.Materials and Methods Eight patients with advanced liver cirrhosis received transplantation of autologous bone marrow stem cells.The data of those were reviewed,and the changes of patient symptoms were observed.Liver function,especially the total bilirubin and albumin were examined in 1 and 3 months after procedure.Results The success was achieved in all 8 patients without obvious complications.There was statistical significance in differences of total bilirubin and albumin pre-and post-procedure.Conclusion The effect is satisfied of transplantation of autologous bone marrow stem cells for the treatment of advanced liver cirrhosis,its long-term curative effect need further observation.

关 键 词：骨髓干细胞 移植 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]