改良电痉挛法联合帕罗西汀治疗首发抑郁症病人的疗效及安全性研究  

THE STUDY OF TREATING PATIENTS WITH FIST-EPISODE DEPRESSION BY MEANS OF MODIFIED ELECTRIC CONVULSIVE THERAPY COMBINING PAROXETINE

作　　者：陈丽霞 田常青 王瑞琴 

机构地区：[1]内蒙古精神卫生中心科教科,内蒙古呼和浩特010010

出　　处：《内蒙古医学院学报》2010年第1期32-35,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古卫生厅医疗卫生科研计划项目(2005040)

摘　　要：目的:探讨改良电痉挛治疗(MECT)对抑郁症治疗的疗效及安全性。方法:将120例首发抑郁症病人随机分为两组,分为单用帕罗西汀(下称对照组)组和帕罗西汀与电痉挛治疗联合应用组(下称联用组),观察时间为8wk。于基线及治疗1、2、4、6、8周末,采用汉密尔顿抑郁量表(HAMD)评定疗效,采用治疗中需处理的不良反应症状量表(TESS)和心电图的改变评价治疗的安全性。最终纳入分析联用组和对照组各58例。结果:联用组自治疗第1wk、对照组自治疗第4wk,HAMD焦虑/躯体化、认识障碍、阻滞、绝望感四个因子分和总分显著下降,与基线的差异具有统计学意义(P<0.05或P<0.01);自治疗第6wk始两组病人的HAMD全部7个因子分相比无统计学差异。8wk观察中未发现二者对心电图有明显影响。结论:改良电痉挛治疗对首发抑郁症的治疗有良好的疗效,而且起效迅速,安全性较好,对记忆功能早期有一定影响,一般在1mo左右恢复。Objective：To discuss therapeutic efficency and safety of MECT in first - episode de- pressive patients. Methods： 120 depressive patients were divied into combined treated group and control group randomly , then observed for 8 weeks. To evaluate therapeutic efficency with HAMD at baseline and lth ,2th ,4th ,6th ,8th weekend. To evaluate therapeutic safety with TESS and electrocardiogram changes. Ultimately we analyzed 58 patients in each group respectively. Results：There were four kinds of factor （ HAMD anxiety/somatization, awareness barriers, block, hopelessness） score and total score have significant decrease since the first weekend in two groups and since the 4th weekend in con- trasted group . There are significant difference contrast with baseline （ P 〈 0.05orP 〈 0.01 ）. There were no significant difference in 7 kinds of factor score of HAMD since 6th weekend in two groups . There are no significant effect to ECG in 8 weeks. Conclusion：MECT shows favorable therapeutic effi- cency and rapid exert effect and nicer safety as well as.

关 键 词：改良电痉挛治疗 帕罗西汀 抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]