血清维生素B_(12)水平与多发性硬化关系的Meta分析  

Meta-analysis of the Relationship between Serum Vitamin B_(12) Level and Multiple Sclerosis

作　　者：朱颖[1] 刘鹤南[2] 张朝东[1] 

机构地区：[1]中国医科大学附属第一医院神经内科,沈阳110001 [2]中国医科大学附属盛京医院眼科,沈阳110004

出　　处：《中国医科大学学报》2010年第3期234-237,共4页Journal of China Medical University

摘　　要：目的综合评价血清维生素B1(2VB12)水平与多发性硬化(MS)的关系。方法联合应用计算机及手工检索,全面检索血清VB12水平与MS病例对照研究的相关文献。对所获文献进行方法学质量评价、筛选和异质性检验。采用Stata10.1软件对提取的数据进行分析。结果共9篇文献进入Meta分析,获得样本807例,其中病例组414例,对照组393例。Meta分析结果显示,MS病例组血清VB12水平显著低于对照组(标准化均差为-0.24,95%可信区间为-0.39^-0.10)。敏感性分析显示2组在血清VB12水平上的差异结果可靠。结论血清VB12水平与MS具有相关性,VB12的缺乏可能在MS的病理过程中发挥作用。Objective To determine the relationship between serum vitamin B12（VB12）level and multiple sclerosis（MS）. Methods The pertinent articles of the VB12 and the case control studies of MS were retrieved comprehensively by manual retrieval and computer retrieval. The methodology quality of the retrieved artilces were evaluated,and the arcticles were screened. Heterogeneity test was performed. The valid data was extracted and analyzed by Stata 10.1. Results In this study,9 studies were included. A total of 807 subjects were enrolled,including 414 patients and 393 controls. The Meta-analysis showed that the serum level of VB12 in patients with MS was lower than that in controls（standardized mean difference -0.24,95% CI -0.39 to -0.10）. The sensitivity analysis indicated that the result of meta-analysis was reliable. Conclusion The serum level of VB12 might be associated with MS,and the deficiency of VB12 may contribute to the development of MS.

关 键 词：维生素B12 多发性硬化 META分析 

分 类 号：R744.5[医药卫生—神经病学与精神病学]