新型肿瘤热疗用温敏凝胶的制备与表征  

Preparation and characterization of a novel thermosensitive gels for tumor hyperthermia

作　　者：刘爱红[1] 孙康宁[2] 李爱民[2] 

机构地区：[1]黄石理工学院化学与材料工程学院,湖北黄石435003 [2]山东大学液态结构及其遗传性教育部重点实验室,山东省工程陶瓷重点实验室,山东济南250061

出　　处：《现代化工》2010年第4期54-56,共3页Modern Chemical Industry

基　　金：国家自然科学基金项目(50672051);黄石理工学院科研项目(09yjz01R)共同资助

摘　　要：采用化学共沉淀结合水热处理的方法,控制一定的反应条件,制备了碳纳米管/四氧化三铁(CNTs/Fe3O4)热种子材料,然后以壳聚糖温敏凝胶为载体,将CNTs/Fe3O4复合材料分散到凝胶中,制备出微波靶向热疗用碳纳米管-四氧化三铁-壳聚糖温敏凝胶。碳纳米管复合热种子材料在凝胶体系中分布均匀,与载体不发生化学反应,25 W下辐照10 min,当CNTs/Fe3O4复合材料的质量浓度为20 mg/mL时,体系温度在初始温度基础上升高了38.7℃,在微波场中具有良好的产热能力,可以满足微波热疗的要求。A CNTs/Fe3O4 thermo-seed material is prepared by a simple and effective coprecipitation and hydrothermal treatment,then carbon nanotubes composite-chitosan thermosensitive gels are prepared and characterized. In this system chitosan thermosensitive gels are used as the carrier with CNTs/Fe3O4 dispersed in it. CNTs composite are dispersed homogeneously in the carrier, and there are no chemical reactions between CNTs composite and gels components. Nano thermal-seed materials has a good heat production capacity in the microwave field, and are distributed uniformly in the gel system. Under these conditions such as microwave radiation of 25 W for 10 minutes and 20 mg/mL of CNTs/Fe3O4 ,the temperature of the system can be increased by 38. 7℃. The result indicates that the thermosensitive gels have significant potential for application in electromagnetic wave absorption in tumor hyperthermia.

关 键 词：碳纳米管 四氧化三铁 壳聚糖 温敏性 热效应 

分 类 号：R318.08[医药卫生—生物医学工程]