食管鳞癌中MTA1、MMP-9和MVD的表达及其临床病理意义  

Expression and clinical pathological significance of MTA1、MMP-9 and MVD in human esophageal squamous cell carcinoma

作　　者：陶识博[1] 张蕾[1] 张云汉[2,3] 高冬玲[2,3] 赵阿红[2,3] 马晓艳[1] 陈妍琼[1] 宋波[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,河南郑州450052 [2]郑州大学第一附属医院病理科,河南郑州450052 [3]河南省肿瘤病理重点实验室,河南郑州450052

出　　处：《河南大学学报（医学版）》2010年第1期29-33,共5页Journal of Henan University:Medical Science

基　　金：河南省高校杰出科研人才创新工程基金项目(2007KYCX005)

摘　　要：目的:探讨转移相关蛋白1(metastasis-associated protein1,MTA1),基质金属蛋白酶-9(matrix metallopro-teinases-9,MMP-9)和微血管密度(microvessel density,MVD)在人食管鳞癌中的表达及其临床病理意义。方法:采用免疫组织化学SP法分别对38例食管正常组织,45例食管癌旁不典型增生组织及64例食管鳞癌组织中MTA1、MMP-9及MVD的表达进行检测。结果:MTA1、MMP-9及MVD在正常组织、不典型增生组织及癌组织之间的表达均呈现逐渐增高趋势,组间比较差异有显著性意义(P<0.01);MTA1和MMP-9与肿瘤患者的性别、年龄及肿瘤的分化程度无关(P>0.05),与肿瘤的浸润深度及淋巴结转移有关(P<0.05);MVD的表达与肿瘤患者的性别、年龄无关(P>0.05),与肿瘤的分化程度、浸润深度及淋巴结转移有关(P<0.05)。结论:MTA1、MMP-9及MVD的高表达与食管鳞癌的浸润及转移有关,联合检测3项指标对判断食管鳞癌的侵袭转移及预后有重要意义。Objective： To investigate the expression and clinical pathological significance of metastasis associated protein1（MTA1）,Matrix metalloproteinases-9（MMP-9）,microvessel density（MVD） in human esophageal squamous cell carcinoma.Methods： Immunnohistochemical technique was carried out to detect the MTA1、MMP-9 and MVD protein among 38 normal tissues,45 atypical hyperplasia tissues and 64 cancer tissue.Results： the expression of MTA1、MMP-9 and MVD in the normal group,atypical hyperplasia group and the cancer group tended to increase,during which the difference was statistically significant（P〈0.01）;MTA1 and MMP-9 expression was closely associated with invasion and lymph node metastasis（P〈0.05）.MVD expression was closely associated with differentiation invasion and lymph node metastasis（P〈0.05）.Conclusion： The high expression of MAT1、MMP-9 and MVD were singnificantly concerned with the invasion and metastasis of the human esophageal Squamous cell carcinoma.Combined detecting of MTA1、MMP-9 and MVD play an important part in judging the invasion,metastasis and the prognosis for esophageal Squamous cell carcinoma.

关 键 词：食管鳞癌 MTA1 MMP-9 MVD 

分 类 号：R735.1[医药卫生—肿瘤]