大黄复方制剂对局灶性脑缺血模型大鼠的影响  

Effect of Rhubarb compound preparations on focal cerebral ischemic model in rats

作　　者：韩紫岩[1] 郭新社[2] 

机构地区：[1]河南大学药学院天然药物化学教研室,河南开封475004 [2]河南大学药学院药物分析教研室,河南开封475004

出　　处：《河南大学学报（医学版）》2010年第1期40-43,共4页Journal of Henan University:Medical Science

摘　　要：目的:研究大黄复方制剂对局灶性脑缺血模型(MACO)大鼠的保护作用。方法:采用大鼠大脑中动脉结扎造模,将大鼠随机分为假手术组、模型组、阳性对照组(尼莫地平)及大黄复方制剂高、中、低剂量组,观察MACO大鼠的神经病学症状、被动性条件反射及给药前后体重改变,测量脑梗死面积。结果:与模型组比较,大黄复方制剂能明显改善MCAO大鼠神经病学症状,延长被动性条件反射潜伏期及减少错误次数,显著缩小脑梗死面积,体重下降程度明显减轻。结论:大黄复方制剂对大鼠局灶性脑缺血损伤具有显著的保护作用。Objective： To study the mechanism of resisting and protecting cerebral ischemia of rhubarb compound preparations on focal cerebral ischemic model in rats.Methods： Applying the model of focal cerebral ischemic.Wistar rats were divided randomly into sham-operated group,model group,nitrendipine group,Rhubarb 1 group（high dosage）,Rhubarb 2 group（medium dosage）Rhubarb 3 group（low dosage）,to see neural symptoms,passively conditioned reflex,the changes of avoirdupois,and the area of brain occlusion.Results： Compared with the model group,neural symptoms,passively conditioned reflex,the changes of avoirdupois the area of brain occlusion were lower in each of the three groups of rhubarb compound preparation.Conclusion： Rhubarb compound preparation have the protective effect on cerebral ischemic rats.

关 键 词：脑缺血 大鼠 大黄 

分 类 号：R364.1[医药卫生—病理学]